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Zhx1 zinc fingers and homeoboxes 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171159, updated on 30-Sep-2021

Summary

Official Symbol
Zhx1provided by RGD
Official Full Name
zinc fingers and homeoboxes 1provided by RGD
Primary source
RGD:620010
See related
EnsemblRapid:ENSRNOG00000006412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may bind the activation domain of the A subunit of nuclear factor-Y to regulate transcription; localized to the nucleus; can form a homodimer in vitro [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 168.2), Brain (RPKM 158.8) and 9 other tissues See more
Orthologs
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Genomic context

See Zhx1 in Genome Data Viewer
Location:
7q33
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89582363..89611337, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (97915280..97944787, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093813 Neighboring gene similar to RIKEN cDNA 9130401M01 Neighboring gene similar to ribosomal protein S10 Neighboring gene ATPase family, AAA domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc fingers and homeoboxes protein 1
Names
zinc finger and homeodomain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133620.2NP_598304.2  zinc fingers and homeoboxes protein 1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000185
    Related
    ENSRNOP00000079752.1, ENSRNOT00000102754.1
    Conserved Domains (4) summary
    smart00389
    Location:665716
    HOX; Homeodomain
    cd00086
    Location:468523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785821
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:98150
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    89582363..89611337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594644.2XP_017450133.1  zinc fingers and homeoboxes protein 1 isoform X1

    UniProtKB/TrEMBL
    G3V6S9
    Related
    ENSRNOP00000079266.1, ENSRNOT00000100253.1
    Conserved Domains (4) summary
    smart00389
    Location:665716
    HOX; Homeodomain
    cd00086
    Location:468523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785821
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:98150
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  2. XM_017594642.2XP_017450131.1  zinc fingers and homeoboxes protein 1 isoform X1

    UniProtKB/TrEMBL
    G3V6S9
    Related
    ENSRNOP00000008454.2, ENSRNOT00000008454.5
    Conserved Domains (4) summary
    smart00389
    Location:665716
    HOX; Homeodomain
    cd00086
    Location:468523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785821
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:98150
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  3. XM_017594643.2XP_017450132.1  zinc fingers and homeoboxes protein 1 isoform X1

    UniProtKB/TrEMBL
    G3V6S9
    Related
    ENSRNOP00000084155.1, ENSRNOT00000112281.1
    Conserved Domains (4) summary
    smart00389
    Location:665716
    HOX; Homeodomain
    cd00086
    Location:468523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785821
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:98150
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  4. XM_039078347.1XP_038934275.1  zinc fingers and homeoboxes protein 1 isoform X1

    Conserved Domains (4) summary
    smart00389
    Location:665716
    HOX; Homeodomain
    cd00086
    Location:468523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785821
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:98150
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

RNA

  1. XR_005486543.1 RNA Sequence

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