Usp15 ubiquitin specific peptidase 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Usp15provided by RGD
Official Full Name: ubiquitin specific peptidase 15provided by RGD
Primary source: RGD:628795
See related: Ensembl:ENSRNOG00000023202 AllianceGenome:RGD:628795
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ubp109
Summary: Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination. Located in cytosol and nucleus. Orthologous to human USP15 (ubiquitin specific peptidase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 335.8), Spleen (RPKM 270.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (60643611..60805137, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (58756714..58848778, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (66595707..66687707)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleviative effect of microRNA-497 on diabetic neuropathic pain in rats in relation to decreased USP15.
Title: Alleviative effect of microRNA-497 on diabetic neuropathic pain in rats in relation to decreased USP15.
USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner.
Title: USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner.
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
Title: USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
Title: Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor binding	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-modified histone reader activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-modified histone reader activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoubiquitinated protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in monoubiquitinated protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in monoubiquitinated protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of antifungal innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of antifungal innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of antifungal innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of RIG-I signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation-coupled chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 15

Names: deubiquitinating enzyme 15; deubiquitinating enzyme Ubp109; ubiquitin carboxyl-terminal hydrolase of 109 kDa; ubiquitin specific protease 15; ubiquitin thioesterase 15; ubiquitin-specific-processing protease 15

NP_660185.1

EC 3.4.19.12

XP_006241493.1

EC 3.4.19.12

XP_008763598.1

EC 3.4.19.12

XP_038934278.1

EC 3.4.19.12

XP_038934279.1

EC 3.4.19.12

XP_038934281.1

EC 3.4.19.12

XP_063119023.1

EC 3.4.19.12

XP_063119024.1

EC 3.4.19.12

XP_063119025.1

EC 3.4.19.12

XP_063119026.1

EC 3.4.19.12

XP_063119027.1

EC 3.4.19.12

XP_063119028.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145184.1 → NP_660185.1 ubiquitin carboxyl-terminal hydrolase 15

See identical proteins and their annotated locations for NP_660185.1

Status: PROVISIONAL

Source sequence(s)

AF106657

UniProtKB/Swiss-Prot

E9PSP9, Q9R085

Related

ENSRNOP00000071983.2, ENSRNOT00000079410.2

Conserved Domains (6) summary

smart00695
Location:24 → 121

DUSP; Domain in ubiquitin-specific proteases

COG5560
Location:12 → 903

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02674
Location:755 → 902

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:261 → 446

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam14533
Location:462 → 568

USP7_C2; Ubiquitin-specific protease C-terminal

pfam14836
Location:135 → 222

Ubiquitin_3; Ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

60643611..60805137 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262953.1 → XP_063119023.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X2
XM_006241431.4 → XP_006241493.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X1

See identical proteins and their annotated locations for XP_006241493.1

UniProtKB/TrEMBL

A0A0A0MY07, A6HQN9

Related

ENSRNOP00000034485.6

Conserved Domains (1) summary

COG5560
Location:12 → 932

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
XM_008765376.4 → XP_008763598.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X4

Conserved Domains (4) summary

cd02674
Location:663 → 810

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:169 → 354

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam14533
Location:370 → 476

USP7_C2; Ubiquitin-specific protease C-terminal

pfam14836
Location:14 → 101

Ubiquitin_3; Ubiquitin-like domain
XM_039078351.2 → XP_038934279.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X8

UniProtKB/TrEMBL

A6HQP0

Conserved Domains (1) summary

COG5560
Location:34 → 683

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
XM_063262956.1 → XP_063119026.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X6
XM_039078350.2 → XP_038934278.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X7

UniProtKB/TrEMBL

A6HQP0

Conserved Domains (1) summary

COG5560
Location:60 → 709

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
XM_039078353.2 → XP_038934281.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X9

UniProtKB/TrEMBL

A6HQP0

Conserved Domains (1) summary

COG5560
Location:1 → 599

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
XM_063262954.1 → XP_063119024.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X3
XM_063262955.1 → XP_063119025.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X5
XM_063262958.1 → XP_063119028.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X11
XM_063262957.1 → XP_063119027.1 ubiquitin carboxyl-terminal hydrolase 15 isoform X10