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Tmem176b transmembrane protein 176B [ Rattus norvegicus (Norway rat) ]

Gene ID: 171411, updated on 13-Apr-2024

Summary

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Official Symbol
Tmem176bprovided by RGD
Official Full Name
transmembrane protein 176Bprovided by RGD
Primary source
RGD:708403
See related
Ensembl:ENSRNOG00000008465 AllianceGenome:RGD:708403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lr8; Torid
Summary
Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. Predicted to be integral component of membrane. Orthologous to human TMEM176B (transmembrane protein 176B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 1548.0), Liver (RPKM 1003.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (79097808..79105263, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77766928..77774740, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78450724..78458600, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 1 Neighboring gene GTPase, IMAP family member 5 Neighboring gene transmembrane protein 176A Neighboring gene amine oxidase, copper containing 1 Neighboring gene DAB2 interacting protein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. Louvet C, et al. Am J Transplant, 2005 Sep. PMID 16095493
  2. Tmem176B and Tmem176A are associated with the immature state of dendritic cells. Condamine T, et al. J Leukoc Biol, 2010 Sep. PMID 20501748
  3. Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. Lurton J, et al. Am J Respir Cell Mol Biol, 1999 Feb. PMID 9922225
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TORID may be involved in the control of DC maturation and may, therefore, play a role in the induction or maintenance of allograft tolerance
    Title: Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72697

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of dendritic cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 176B
Names
TORID
tolerance-related and induced transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270589.1 → NP_001257518.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001257518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    BC059116, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q925D4
    UniProtKB/TrEMBL
    A6K0I4, A6K0I5
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  2. NM_001270590.1 → NP_001257519.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001257519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    BC059116, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q925D4
    UniProtKB/TrEMBL
    A6K0I4, A6K0I5
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  3. NM_001270591.1 → NP_001257520.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001257520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    BC059116, FN804490, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q925D4
    UniProtKB/TrEMBL
    A6K0I4, A6K0I5
    Related
    ENSRNOP00000011327.3, ENSRNOT00000011327.7
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  4. NM_001270592.1 → NP_001257521.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001257521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    BC059116, FM086181, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q925D4
    UniProtKB/TrEMBL
    A6K0I4, A6K0I5
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  5. NM_001270593.1 → NP_001257522.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001257522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    BC059116, FM070640, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q925D4
    UniProtKB/TrEMBL
    A6K0I4, A6K0I5
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  6. NM_001270594.1 → NP_001257523.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_001257523.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
    Source sequence(s)
    BC059116, FM070640, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q925D4
    UniProtKB/TrEMBL
    A6K0I4, A6K0I5
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

  7. NM_134390.3 → NP_599217.1  transmembrane protein 176B

    See identical proteins and their annotated locations for NP_599217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All seven variants encode the same protein.
    Source sequence(s)
    BC059116, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q925D4
    UniProtKB/TrEMBL
    A6K0I4, A6K0I5
    Conserved Domains (1) summary
    pfam04103
    Location:60 → 224
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    79097808..79105263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925D4.1 GenPept UniProtKB/Swiss-Prot:Q925D4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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