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Cd99l2 CD99 molecule-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171485, updated on 3-Apr-2024

Summary

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Symbol
Cd99l2provided by RGD
Full Name
CD99 molecule-like 2provided by RGD
Primary source
RGD:620896
See related
AllianceGenome:RGD:620896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mic2l1; vms-tm2
Summary
Predicted to be involved in cell adhesion. Predicted to act upstream of or within diapedesis; homotypic cell-cell adhesion; and positive regulation of cellular extravasation. Is integral component of membrane. Orthologous to human CD99L2 (CD99 molecule like 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Brain (RPKM 123.5), Kidney (RPKM 101.9) and 9 other tissues See more
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Genomic context

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Location:
15p16
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (6861242..6906838, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (5265257..5311232)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 14-like Neighboring gene disks large homolog 5-like Neighboring gene disks large homolog 5-like Neighboring gene uncharacterized LOC134481942

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of Rhombex-40 a transmembrane protein from the ventral medullary surface of the rat brain by differential display. Shimokawa N, et al. Life Sci, 2000 Apr 21. PMID 10834302
  2. Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. Seelige R, et al. J Immunol, 2013 Feb 1. PMID 23293350
  3. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. Suh YH, et al. Gene, 2003 Mar 27. PMID 12706889
  4. A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo. Bixel MG, et al. Blood, 2007 Jun 15. PMID 17344467
  5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within diapedesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of T cell extravasation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD99 antigen-like protein 2
Names
CD99 antigen-like protein 2-like
Cd99 antigen-like 2
MIC2 like 1
MIC2-like protein 1
Rhombex-40
protein rhombex-40
rhombencephalic expression protein 40 kDa
single-pass transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409570.1 → NP_001396499.1  CD99 antigen-like protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVV010002890
    UniProtKB/Swiss-Prot
    Q8R1R5, Q9JJL7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    6861242..6906838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273956.1 → XP_063130026.1  CD99 antigen-like protein 2 isoform X2

  2. XM_063273955.1 → XP_063130025.1  CD99 antigen-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8R1R5, Q9JJL7

  3. XM_063273957.1 → XP_063130027.1  CD99 antigen-like protein 2 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_134459.1: Suppressed sequence

    Description
    NM_134459.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1R5.1 GenPept UniProtKB/Swiss-Prot:Q8R1R5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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