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Cd99l2 CD99 antigen-like 2 [ Mus musculus (house mouse) ]

Gene ID: 171486, updated on 5-Mar-2024

Summary

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Official Symbol
Cd99l2provided by MGI
Official Full Name
CD99 antigen-like 2provided by MGI
Primary source
MGI:MGI:2177151
See related
Ensembl:ENSMUSG00000035776 AllianceGenome:MGI:2177151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xap89; Mic2l1
Summary
Acts upstream of or within diapedesis; homotypic cell-cell adhesion; and positive regulation of cellular extravasation. Located in adherens junction and cell surface. Is expressed in several structures, including alimentary system; hemolymphoid system; nervous system; reproductive system; and skin. Orthologous to human CD99L2 (CD99 molecule like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 23.1), whole brain E14.5 (RPKM 17.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A7.3; X 36.82 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (70463666..70536467, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (71420060..71492866, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7692 Neighboring gene STARR-seq mESC enhancer starr_47322 Neighboring gene X-linked myotubular myopathy gene 1 Neighboring gene myotubularin related protein 1 Neighboring gene STARR-seq mESC enhancer starr_47323 Neighboring gene STARR-seq mESC enhancer starr_47324 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chrX:68808842-68809143 Neighboring gene high mobility group box 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation. Samus M, et al. J Leukoc Biol, 2018 Oct. PMID 29791026
  2. CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory response. Rutledge NS, et al. Exp Mol Pathol, 2015 Dec. PMID 26321243, Free PMC Article
  3. Effect of shRNA targeting mouse CD99L2 gene in a murine B cell lymphoma in vitro and in vivo. Liu F, et al. Oncol Rep, 2013 Apr. PMID 23338758
  4. [Expression and cloning of mCD99L2 gene from mouse B lymphoma cell line A20 and construction of its eukaryotic expression vector]. Shen LJ, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2006 Feb. PMID 16503515
  5. Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. Seelige R, et al. J Immunol, 2013 Feb 1. PMID 23293350

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conditional Tie-2-Cre driven gene inactivation of CD99L2 inhibits leukocyte entry into the CNS during active MOG35-55 -induced experimental autoimmune encephalomyelitis and alleviates severity of the disease. CD99L2 participates in the development of EAE by supporting diapedesis of leukocytes through the endothelial basement membrane of blood vessels of the BBB in the CNS.
    Title: CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation.
  2. Mice lacking CD99L2 had a defective inflammatory response in the thioglycollate peritonitis model
    Title: CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory response.
  3. The present study provides data for further investigation into the mCD99L2 gene in tumor cells.
    Title: Effect of shRNA targeting mouse CD99L2 gene in a murine B cell lymphoma in vitro and in vivo.
  4. CD99L2 is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes.
    Title: Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo.
  5. Transfection of L cell fibroblasts with CD99L2 imparted to them the ability to adhere to each other in a divalent cation-dependent, homophilic manner. Anti-CD99L2 antibody blocked influx of neutrophils and monocytes into a site of inflammation in vivo.
    Title: The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response.
  6. expressed on mouse leukocytes and endothelial cells and is involved in transendothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum
    Title: A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within diapedesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell extravasation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neutrophil extravasation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
CD99 antigen-like protein 2
Names
MIC2 (monoclonal Imperial Cancer Research Fund 2)-like 1
MIC2 like-1
MIC2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199349.1 → NP_001186278.1  CD99 antigen-like protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001186278.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK080225, BF147574, BY727540
    Consensus CDS
    CCDS57761.1
    UniProtKB/Swiss-Prot
    A2AP77, Q8BIF0, Q8R447
    UniProtKB/TrEMBL
    A2AP74
    Related
    ENSMUSP00000042606.6, ENSMUST00000037391.12
    Conserved Domains (1) summary
    pfam12301
    Location:30 → 215
    CD99L2; CD99 antigen like protein 2

  2. NM_138309.3 → NP_612182.1  CD99 antigen-like protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_612182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK080225, AY078163, BF147574, BY727540
    Consensus CDS
    CCDS30179.1
    UniProtKB/TrEMBL
    I7HJQ8
    Related
    ENSMUSP00000078944.5, ENSMUST00000080035.11
    Conserved Domains (1) summary
    pfam12301
    Location:30 → 192
    CD99L2; CD99 antigen like protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    70463666..70536467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527887.5 → XP_006527950.1  CD99 antigen-like protein 2 isoform X2

    UniProtKB/TrEMBL
    I7HJQ8
    Conserved Domains (1) summary
    pfam12301
    Location:30 → 198
    CD99L2; CD99 antigen like protein 2

  2. XM_006527886.5 → XP_006527949.1  CD99 antigen-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A2AP74
    Conserved Domains (1) summary
    pfam12301
    Location:30 → 221
    CD99L2; CD99 antigen like protein 2

  3. XM_011247540.3 → XP_011245842.1  CD99 antigen-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011245842.1

    Conserved Domains (2) summary
    pfam12301
    Location:65 → 144
    CD99L2; CD99 antigen like protein 2
    cl19816
    Location:24 → 71
    Hydantoinase_B; Hydantoinase B/oxoprolinase

  4. XM_017318407.3 → XP_017173896.1  CD99 antigen-like protein 2 isoform X4

    Conserved Domains (2) summary
    pfam12301
    Location:65 → 138
    CD99L2; CD99 antigen like protein 2
    cl19816
    Location:24 → 71
    Hydantoinase_B; Hydantoinase B/oxoprolinase

  5. XM_011247541.3 → XP_011245843.1  CD99 antigen-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011245843.1

    Conserved Domains (2) summary
    pfam12301
    Location:65 → 144
    CD99L2; CD99 antigen like protein 2
    cl19816
    Location:24 → 71
    Hydantoinase_B; Hydantoinase B/oxoprolinase

  6. XM_011247542.4 → XP_011245844.1  CD99 antigen-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011245844.1

    Conserved Domains (2) summary
    pfam12301
    Location:65 → 144
    CD99L2; CD99 antigen like protein 2
    cl19816
    Location:24 → 71
    Hydantoinase_B; Hydantoinase B/oxoprolinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIF0.1 GenPept UniProtKB/Swiss-Prot:Q8BIF0

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