U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sgk3 serum/glucocorticoid regulated kinase family, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171498, updated on 25-Apr-2024

Summary

Go to the top of the page Help
Symbol
Sgk3provided by RGD
Full Name
serum/glucocorticoid regulated kinase family, member 3provided by RGD
Primary source
RGD:620242
See related
Ensembl:ENSRNOG00000049052 AllianceGenome:RGD:620242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cisk; Sgkl
Summary
Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in cytoplasmic vesicle and nucleoplasm. Orthologous to several human genes including C8orf44-SGK3 (C8orf44-SGK3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 103.9), Thymus (RPKM 90.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sgk3 in Genome Data Viewer
Location:
5q11
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14128628..14255099, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9345761..9472243, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (9046889..9094740, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556004 Neighboring gene transcription factor 24 Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 4 Neighboring gene interferon-induced transmembrane protein 2-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MiR-155 modulates the progression of neuropathic pain through targeting SGK3. Liu S, et al. Int J Clin Exp Pathol, 2015. PMID 26823753, Free PMC Article
  2. Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival. Liu D, et al. Curr Biol, 2000 Oct 5. PMID 11050396
  3. Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. Dai F, et al. Genomics, 1999 Nov 15. PMID 10585774
  4. The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11. Lamothe SM, et al. J Biol Chem, 2013 May 24. PMID 23589291, Free PMC Article
  5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-155 modulates the progression of neuropathic pain through SGK3 signaling.
    Title: MiR-155 modulates the progression of neuropathic pain through targeting SGK3.
  2. SGK1,3 enhances the expression level of mature hERG channels by inhibiting Nedd4-2 as well as by promoting Rab11-mediated hERG recycling.
    Title: The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein kinase Sgk3
Names
cytokine-independent survival kinase
serum/glucocorticoid-regulated kinase 3
NP_001362972.1
XP_038965159.1
XP_038965160.1
XP_038965161.1
XP_063143190.1
XP_063143191.1
XP_063143192.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376043.1 → NP_001362972.1  serine/threonine-protein kinase Sgk3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q8R4V0
    UniProtKB/TrEMBL
    M0R582
    Related
    ENSRNOP00000064540.3, ENSRNOT00000072210.3
    Conserved Domains (2) summary
    cd06870
    Location:12 → 120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    cd05604
    Location:165 → 490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    14128628..14255099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109233.2 → XP_038965161.1  serine/threonine-protein kinase Sgk3 isoform X1

    UniProtKB/Swiss-Prot
    Q8R4V0
    UniProtKB/TrEMBL
    M0R582
    Conserved Domains (2) summary
    cd06870
    Location:12 → 120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    cd05604
    Location:165 → 490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

  2. XM_063287121.1 → XP_063143191.1  serine/threonine-protein kinase Sgk3 isoform X1

    UniProtKB/TrEMBL
    M0R582

  3. XM_039109232.2 → XP_038965160.1  serine/threonine-protein kinase Sgk3 isoform X1

    UniProtKB/Swiss-Prot
    Q8R4V0
    UniProtKB/TrEMBL
    M0R582
    Conserved Domains (2) summary
    cd06870
    Location:12 → 120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    cd05604
    Location:165 → 490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

  4. XM_039109231.2 → XP_038965159.1  serine/threonine-protein kinase Sgk3 isoform X1

    UniProtKB/Swiss-Prot
    Q8R4V0
    UniProtKB/TrEMBL
    M0R582
    Conserved Domains (2) summary
    cd06870
    Location:12 → 120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    cd05604
    Location:165 → 490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

  5. XM_063287120.1 → XP_063143190.1  serine/threonine-protein kinase Sgk3 isoform X1

    UniProtKB/TrEMBL
    M0R582

  6. XM_063287122.1 → XP_063143192.1  serine/threonine-protein kinase Sgk3 isoform X1

    UniProtKB/TrEMBL
    M0R582
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4V0.2 GenPept UniProtKB/Swiss-Prot:Q8R4V0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous