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Cxcl3 C-X-C motif chemokine ligand 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171551, updated on 6-May-2021

Summary

Official Symbol
Cxcl3provided by RGD
Official Full Name
C-X-C motif chemokine ligand 3provided by RGD
Primary source
RGD:621812
See related
Ensembl:ENSRNOG00000028043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cinc2; Cinc-2; Gm1960
Summary
acts as a chemoattractant for neutrophils; involved in the inflammatory response [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 1106.6) See more
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Genomic context

See Cxcl3 in Genome Data Viewer
Location:
14p22
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17270146..17289458, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18820168..18839659, complement)

Chromosome 14 - NC_051349.1Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 1 Neighboring gene similar to Alpha-enolase (2-phospho-D-glycerate hydro-lyase) (Non-neural enolase) (NNE) (Enolase 1) Neighboring gene uncharacterized LOC102549742 Neighboring gene platelet factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in killing of cells of other organism ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
C-X-C motif chemokine 3
Names
MIP2-alpha/beta
chemokine (C-X-C motif) ligand 3
cytokine-induced neutrophil chemoattractant 2
macrophage inflammatory protein 2-alpha/beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394590.1NP_001381519.1  C-X-C motif chemokine 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000250

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051349.1 Reference mRatBN7.2 Primary Assembly

    Range
    17270146..17289458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250721.4XP_006250783.1  C-X-C motif chemokine 3 isoform X1

    UniProtKB/Swiss-Prot
    Q10746
    Related
    ENSRNOP00000070985.1
    Conserved Domains (1) summary
    cd00273
    Location:3496
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138522.1: Suppressed sequence

    Description
    NM_138522.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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