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POLR3H RNA polymerase III subunit H [ Homo sapiens (human) ]

Gene ID: 171568, updated on 8-Jul-2021

Summary

Official Symbol
POLR3Hprovided by HGNC
Official Full Name
RNA polymerase III subunit Hprovided by HGNC
Primary source
HGNC:HGNC:30349
See related
Ensembl:ENSG00000100413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C25; RPC8; RPC22.9
Expression
Ubiquitous expression in heart (RPKM 36.2), kidney (RPKM 22.6) and 25 other tissues See more
Orthologs
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Genomic context

See POLR3H in Genome Data Viewer
Location:
22q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (41525799..41544606, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41921803..41940610, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 5A Neighboring gene aconitase 2 Neighboring gene Sharpr-MPRA regulatory region 731 Neighboring gene uncharacterized LOC105373044 Neighboring gene cold shock domain containing C2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1665, MGC29654, MGC111097

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed 5'-3' RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC8
Names
DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide
DNA-directed RNA polymerase III subunit H
RNA nucleotidyltransferase (DNA-directed)
RNA polymerase III subunit C8
polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
polymerase (RNA) III subunit H
NP_001018060.1
NP_001018062.1
NP_001269813.1
NP_001269814.1
NP_612211.1
XP_011528295.1
XP_016884130.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018050.4NP_001018060.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

    See identical proteins and their annotated locations for NP_001018060.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 5, and 6 encode the same isoform (a).
    Source sequence(s)
    AB051452, AK000365, AL023553, BM701572, DA238361, DA449644
    Consensus CDS
    CCDS14018.1
    UniProtKB/Swiss-Prot
    Q9Y535
    UniProtKB/TrEMBL
    A0A024R1P3
    Related
    ENSP00000347345.4, ENST00000355209.9
    Conserved Domains (2) summary
    cd04330
    Location:281
    RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...
    pfam08292
    Location:83201
    RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
  2. NM_001018052.4NP_001018062.1  DNA-directed RNA polymerase III subunit RPC8 isoform b

    See identical proteins and their annotated locations for NP_001018062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB051452, AK000365, AL023553, BC017248, BM701572, DA238361, DA449644
    Consensus CDS
    CCDS33651.1
    UniProtKB/Swiss-Prot
    Q9Y535
    Related
    ENSP00000337627.5, ENST00000337566.9
    Conserved Domains (2) summary
    cd04330
    Location:270
    RNAP_III_Rpc25_N; RNAP_III_Rpc25_N: Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, ...
    pfam08292
    Location:69172
    RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
  3. NM_001282884.2NP_001269813.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

    See identical proteins and their annotated locations for NP_001269813.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 5, and 6 encode the same isoform (a).
    Source sequence(s)
    AB051452, AK000365, AL023553, BM701572, BU584298
    Consensus CDS
    CCDS14018.1
    UniProtKB/Swiss-Prot
    Q9Y535
    UniProtKB/TrEMBL
    A0A024R1P3
    Related
    ENSP00000385315.1, ENST00000407461.5
    Conserved Domains (2) summary
    cd04330
    Location:281
    RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...
    pfam08292
    Location:83201
    RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
  4. NM_001282885.2NP_001269814.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

    See identical proteins and their annotated locations for NP_001269814.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 5, and 6 encode the same isoform (a).
    Source sequence(s)
    AB051452, AK000365, AL023553, BM701572, BU173504, DA449644
    Consensus CDS
    CCDS14018.1
    UniProtKB/Swiss-Prot
    Q9Y535
    UniProtKB/TrEMBL
    A0A024R1P3
    Conserved Domains (2) summary
    cd04330
    Location:281
    RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...
    pfam08292
    Location:83201
    RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
  5. NM_138338.5NP_612211.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

    See identical proteins and their annotated locations for NP_612211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 3, 5, and 6 encode the same isoform (a).
    Source sequence(s)
    AB051452, AK000365, AL023553, BM701572, DA504810
    Consensus CDS
    CCDS14018.1
    UniProtKB/Swiss-Prot
    Q9Y535
    UniProtKB/TrEMBL
    A0A024R1P3
    Related
    ENSP00000379761.2, ENST00000396504.6
    Conserved Domains (2) summary
    cd04330
    Location:281
    RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...
    pfam08292
    Location:83201
    RNA_pol_Rbc25; RNA polymerase III subunit Rpc25

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    41525799..41544606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529993.1XP_011528295.1  DNA-directed RNA polymerase III subunit RPC8 isoform X1

    Conserved Domains (1) summary
    pfam08292
    Location:33138
    RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
  2. XM_017028641.1XP_016884130.1  DNA-directed RNA polymerase III subunit RPC8 isoform X1

    Conserved Domains (1) summary
    pfam08292
    Location:33138
    RNA_pol_Rbc25; RNA polymerase III subunit Rpc25

RNA

  1. XR_244356.3 RNA Sequence

    Related
    ENST00000431534.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001018051.1: Suppressed sequence

    Description
    NM_001018051.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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