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Mbp myelin basic protein [ Mus musculus (house mouse) ]

Gene ID: 17196, updated on 29-May-2021

Summary

Official Symbol
Mbpprovided by MGI
Official Full Name
myelin basic proteinprovided by MGI
Primary source
MGI:MGI:96925
See related
Ensembl:ENSMUSG00000041607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
jv; Hmb; jve; mld; shi; goll; Hmbpr; C76307; R75289; golli-mbp
Summary
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
Expression
Biased expression in cerebellum adult (RPKM 425.3), cortex adult (RPKM 253.5) and 1 other tissue See more
Orthologs
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Genomic context

See Mbp in Genome Data Viewer
Location:
18 E3; 18 55.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (82492883..82603762)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (82475091..82585637)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (82644515..82755029)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene galanin receptor 1 Neighboring gene ribosomal protein L21, pseudogene 8 Neighboring gene uncharacterized LOC118568383 Neighboring gene zinc finger protein 236 Neighboring gene predicted gene, 50351 Neighboring gene microRNA 5112

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in compact myelin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in compact myelin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in internode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in internode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath HDA PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myelin basic protein; Golli-Mbp
Names
myelin A1 protein
myelin basic protein transcript variant X5
myelin deficient
shiverer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025245.1NP_001020416.1  Golli-Mbp isoform 2

    See identical proteins and their annotated locations for NP_001020416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains 3 exons unique to Golli-Mbp and exon 1 of the classic Mbp. It encodes the shorter of the Golli-Mbp isoforms (2).
    Source sequence(s)
    AC117825, AK039047, AK040716
    Consensus CDS
    CCDS29374.1
    UniProtKB/Swiss-Prot
    P04370
    UniProtKB/TrEMBL
    Q5D096
    Related
    ENSMUSP00000089393.5, ENSMUST00000091789.11
    Conserved Domains (1) summary
    pfam01669
    Location:147193
    Myelin_MBP; Myelin basic protein
  2. NM_001025251.2NP_001020422.1  myelin basic protein isoform 1

    See identical proteins and their annotated locations for NP_001020422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest of the classic Mbp isoforms (1).
    Source sequence(s)
    AC119259, BF457157, BY245551, CO425201
    Consensus CDS
    CCDS29376.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000121855.3, ENSMUST00000123251.9
    Conserved Domains (1) summary
    pfam01669
    Location:14194
    Myelin_MBP; Myelin basic protein
  3. NM_001025254.2NP_001020425.1  myelin basic protein isoform 2

    See identical proteins and their annotated locations for NP_001020425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exon 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (2) that is missing a 11 aa segment compared to isoform 1.
    Source sequence(s)
    BB633793, BC004704
    Consensus CDS
    CCDS37875.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000114630.3, ENSMUST00000153478.9
    Conserved Domains (1) summary
    pfam01669
    Location:14183
    Myelin_MBP; Myelin basic protein
  4. NM_001025255.2NP_001020426.1  myelin basic protein isoform 3

    See identical proteins and their annotated locations for NP_001020426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks exon 2 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (3) that is missing a 26 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, BY245551, CK623660
    Consensus CDS
    CCDS29377.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000115082.3, ENSMUST00000142850.9
    Conserved Domains (1) summary
    pfam01669
    Location:14168
    Myelin_MBP; Myelin basic protein
  5. NM_001025256.2NP_001020427.1  myelin basic protein isoform 4

    See identical proteins and their annotated locations for NP_001020427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks exon 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (4) that is missing a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, AK079621, BY245551
    Consensus CDS
    CCDS29378.1
    UniProtKB/Swiss-Prot
    P04370
    UniProtKB/TrEMBL
    Q542T4
    Related
    ENSMUSP00000115409.3, ENSMUST00000152071.9
    Conserved Domains (1) summary
    pfam01669
    Location:14148
    Myelin_MBP; Myelin basic protein
  6. NM_001025258.2NP_001020429.1  myelin basic protein isoform 5

    See identical proteins and their annotated locations for NP_001020429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks exons 2 and 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (5) that is missing a 26 aa and a 11 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, BY245551, M15062
    Consensus CDS
    CCDS29379.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000114230.3, ENSMUST00000132369.3
    Conserved Domains (1) summary
    pfam01669
    Location:14157
    Myelin_MBP; Myelin basic protein
  7. NM_001025259.2NP_001020430.1  myelin basic protein isoform 6

    See identical proteins and their annotated locations for NP_001020430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks exons 2 and 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (6) that is missing a 26 aa and a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, AK005129, BY245551
    Consensus CDS
    CCDS89290.1
    UniProtKB/Swiss-Prot
    P04370
    UniProtKB/TrEMBL
    Q3UGF3
    Related
    ENSMUSP00000116019.3, ENSMUST00000133193.9
    Conserved Domains (1) summary
    pfam01669
    Location:14122
    Myelin_MBP; Myelin basic protein
  8. NM_010777.3NP_034907.1  Golli-Mbp isoform 1

    See identical proteins and their annotated locations for NP_034907.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains 3 exons unique to Golli-Mbp and exons 1, 3, 4 and 7 of the classic Mbp. It encodes the longer of the Golli-Mbp isoforms (1).
    Source sequence(s)
    AC117825, AC119259, L07507
    Consensus CDS
    CCDS29373.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000046185.8, ENSMUST00000047865.14
    Conserved Domains (1) summary
    pfam01669
    Location:147249
    Myelin_MBP; Myelin basic protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    82492883..82603762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526452.5XP_006526515.1  Golli-Mbp isoform X1

    Conserved Domains (1) summary
    pfam01669
    Location:147349
    Myelin_MBP; Myelin basic protein
  2. XM_006526455.3XP_006526518.1  Golli-Mbp isoform X5

    Conserved Domains (1) summary
    pfam01669
    Location:147308
    Myelin_MBP; Myelin basic protein
  3. XM_006526453.4XP_006526516.1  Golli-Mbp isoform X2

    Conserved Domains (1) summary
    pfam01669
    Location:147327
    Myelin_MBP; Myelin basic protein
  4. XM_006526457.4XP_006526520.1  Golli-Mbp isoform X8

    See identical proteins and their annotated locations for XP_006526520.1

    Conserved Domains (1) summary
    pfam01669
    Location:147274
    Myelin_MBP; Myelin basic protein
  5. XM_036161011.1XP_036016904.1  Golli-Mbp isoform X4

    Conserved Domains (1) summary
    pfam01669
    Location:147317
    Myelin_MBP; Myelin basic protein
  6. XM_006526454.4XP_006526517.1  Golli-Mbp isoform X3

    Conserved Domains (1) summary
    pfam01669
    Location:147324
    Myelin_MBP; Myelin basic protein
  7. XM_030250358.2XP_030106218.1  Golli-Mbp isoform X9

    Conserved Domains (1) summary
    pfam01669
    Location:147282
    Myelin_MBP; Myelin basic protein
  8. XM_006526458.4XP_006526521.1  Golli-Mbp isoform X10

    Conserved Domains (1) summary
    pfam01669
    Location:147248
    Myelin_MBP; Myelin basic protein
  9. XM_006526456.4XP_006526519.1  Golli-Mbp isoform X6

    Conserved Domains (1) summary
    pfam01669
    Location:147301
    Myelin_MBP; Myelin basic protein
  10. XM_036161013.1XP_036016906.1  Golli-Mbp isoform X7

    Conserved Domains (1) summary
    pfam01669
    Location:147291
    Myelin_MBP; Myelin basic protein
  11. XM_036161014.1XP_036016907.1  myelin basic protein isoform X11

    Conserved Domains (1) summary
    pfam01669
    Location:14217
    Myelin_MBP; Myelin basic protein
  12. XM_036161010.1XP_036016903.1  Golli-Mbp isoform X3

    Conserved Domains (1) summary
    pfam01669
    Location:147324
    Myelin_MBP; Myelin basic protein
  13. XM_030250356.1XP_030106216.1  Golli-Mbp isoform X1

    Conserved Domains (1) summary
    pfam01669
    Location:147349
    Myelin_MBP; Myelin basic protein
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