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Mcf2l mcf.2 transforming sequence-like [ Mus musculus (house mouse) ]

Gene ID: 17207, updated on 6-Jul-2021

Summary

Official Symbol
Mcf2lprovided by MGI
Official Full Name
mcf.2 transforming sequence-likeprovided by MGI
Primary source
MGI:MGI:103263
See related
Ensembl:ENSMUSG00000031442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Db; Dbs; Ost; mKIAA0362; C130040G20Rik
Expression
Broad expression in CNS E18 (RPKM 14.7), frontal lobe adult (RPKM 13.1) and 22 other tissues See more
Orthologs
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Genomic context

See Mcf2l in Genome Data Viewer
Location:
8; 8 A1.1
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (12923806..13070502)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (12873806..13020502)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (12915893..13020509)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33587 Neighboring gene ATPase, class VI, type 11A Neighboring gene predicted gene 15350 Neighboring gene predicted gene 15353 Neighboring gene predicted gene 15351 Neighboring gene microRNA 9768 Neighboring gene predicted gene, 53398 Neighboring gene CD24a antigen pseudogene Neighboring gene coagulation factor VII

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide exchange factor DBS
Names
DBL's big sister
MCF2-transforming sequence-like protein
Ost gamma
exchange factor for RhoA and Cdc42
guanine nucleotide exchange factor OSTIII

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159485.2NP_001152957.1  guanine nucleotide exchange factor DBS isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' and 3' coding regions, compared to variant 1, resulting in an isoform (3) that has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AC127308
    Consensus CDS
    CCDS52483.1
    UniProtKB/TrEMBL
    E9PY13, Q6PDM6
    Related
    ENSMUSP00000106490.3, ENSMUST00000110866.9
    Conserved Domains (6) summary
    cd11857
    Location:10071061
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:24169
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:581758
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:300502
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:765896
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:779893
    PH; PH domain
  2. NM_001159486.2NP_001152958.1  guanine nucleotide exchange factor DBS isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (2) that has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC127308
    Consensus CDS
    CCDS52482.1
    UniProtKB/TrEMBL
    E9PY12, Q6PDM6
    Related
    ENSMUSP00000106491.3, ENSMUST00000110867.9
    Conserved Domains (6) summary
    cd11857
    Location:10071061
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:24169
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:581758
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:300502
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:765896
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:779893
    PH; PH domain
  3. NM_001371043.1NP_001357972.1  guanine nucleotide exchange factor DBS isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127308, AC134581
    Consensus CDS
    CCDS90372.1
    Related
    ENSMUSP00000093108.4, ENSMUST00000095456.10
    Conserved Domains (5) summary
    cd11857
    Location:10591113
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:633810
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352554
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:817948
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  4. NM_001371044.1NP_001357973.1  guanine nucleotide exchange factor DBS isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC127308
    Related
    ENSMUSP00000106503.3, ENSMUST00000110879.9
    Conserved Domains (5) summary
    cd11857
    Location:10541108
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:603780
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322524
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:787918
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  5. NM_001371045.1NP_001357974.1  guanine nucleotide exchange factor DBS isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC127308
    Related
    ENSMUSP00000106495.2, ENSMUST00000110871.8
    Conserved Domains (5) summary
    cd11857
    Location:10271081
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:601778
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320522
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:785916
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  6. NM_001371046.1NP_001357975.1  guanine nucleotide exchange factor DBS isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC127308
    Conserved Domains (5) summary
    cd11857
    Location:10251079
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:574751
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:293495
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:758889
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  7. NM_001371047.1NP_001357976.1  guanine nucleotide exchange factor DBS isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC127308
    Conserved Domains (5) summary
    cd11857
    Location:10541108
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:603780
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322524
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:787918
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  8. NM_001371048.1NP_001357977.1  guanine nucleotide exchange factor DBS isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC127308
    Conserved Domains (5) summary
    cd11857
    Location:10831137
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:601778
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320522
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:785916
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  9. NM_001371049.1NP_001357978.1  guanine nucleotide exchange factor DBS isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) encodes the longest isoform (10).
    Source sequence(s)
    AC127308
    Related
    ENSMUSP00000133577.2, ENSMUST00000145067.8
    Conserved Domains (5) summary
    cd11857
    Location:10821136
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:603780
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322524
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:787918
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  10. NM_001371050.1NP_001357979.1  guanine nucleotide exchange factor DBS isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC127308
    Related
    ENSMUSP00000096528.4, ENSMUST00000098927.10
    Conserved Domains (5) summary
    cd11857
    Location:10331087
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:607784
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326528
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:791922
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  11. NM_178076.4NP_835177.2  guanine nucleotide exchange factor DBS isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC127308
    Consensus CDS
    CCDS40225.2
    UniProtKB/TrEMBL
    E9PXE2, Q6PDM6, Q8C474
    Related
    ENSMUSP00000106500.3, ENSMUST00000110876.9
    Conserved Domains (6) summary
    cd11857
    Location:10851139
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:603780
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322524
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:787918
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:801915
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    12923806..13070502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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