Rdh11 retinol dehydrogenase 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rdh11provided by MGI
Official Full Name: retinol dehydrogenase 11provided by MGI
Primary source: MGI:MGI:102581
See related: Ensembl:ENSMUSG00000066441 AllianceGenome:MGI:102581
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mdt1; Psdr1; SCALD; ralR1; Arsdr1; CGI-82; HCBP12; M42C60; Ube-1c; UBE-1c1; 2610319N22Rik
Summary: Enables aldehyde dehydrogenase (NADP+) activity. Involved in cellular detoxification of aldehyde; retinol metabolic process; and visual perception. Acts upstream of or within adaptation of rhodopsin mediated signaling. Located in photoreceptor inner segment. Is expressed in cerebral cortex ventricular layer and diencephalon. Orthologous to human RDH11 (retinol dehydrogenase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 59.5), liver E18 (RPKM 35.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 35.51 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (79221007..79238629, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (79174233..79191855, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that in mouse testis and liver, RDH11 functions as an all-trans-retinaldehyde reductase essential for the maintenance of physiological levels of all-trans-retinol under reduced vitamin A availability
Title: Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in mice.
Oxidative stress induced by exposure to constant bright light led to a rapid and significant decrease of RDH12 protein. The low and constant expression of RDH11 suggested a housekeeping function for this enzyme.
Title: Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress.
RDH11 has a measurable role in regenerating the visual pigment by complementing RDH5 in retinal pigment epithelium.
Title: Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo.
propose that mouse retinol dehydrogenase 11(mRDH11) disruption affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptation through modulation of calcium homeostasis
Title: Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo.
characterization of catalytic properties and tissue distribution
Title: Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins.
RDH11 localizes to photoreceptor inner segments [review]
Title: Photoreceptor retinol dehydrogenases. An attempt to characterize the function of Rdh11.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rdh11 (e-PCR), detects polymorphism
- UniSTS:254234

RH127244 (e-PCR)
- UniSTS:208824

AU016487 (e-PCR)
- UniSTS:208827

AU045252 (e-PCR)
- UniSTS:160219

AI428145 (e-PCR)
- UniSTS:160220

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aldehyde dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables all-trans-retinol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of aldehyde	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular detoxification of aldehyde	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
NOT located_in photoreceptor outer segment membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: retinol dehydrogenase 11

Names: all-trans and 9-cis; androgen-regulated short-chain dehydrogenase/reductase 1; cell line MC/9.IL4 derived transcript 1; cell line MC/9.IL4-derived protein 1; prostate short-chain dehydrogenase/reductase 1; retinal reductase 1; short-chain aldehyde dehydrogenase

NP_001349198.1

EC 1.1.1.300

NP_001349199.1

EC 1.1.1.300

NP_067532.2

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362269.1 → NP_001349198.1 retinol dehydrogenase 11 isoform 2

Status: VALIDATED

Source sequence(s)

AC154585

Consensus CDS

CCDS88359.1

UniProtKB/TrEMBL

Q9R1R8, Q9R1R9

Related

ENSMUSP00000082352.7, ENSMUST00000085254.7

Conserved Domains (1) summary

cl25409
Location:22 → 290

SDR; Short-chain dehydrogenases/reductases (SDR)
NM_001362270.1 → NP_001349199.1 retinol dehydrogenase 11 isoform 3

Status: VALIDATED

Source sequence(s)

AC154585

UniProtKB/TrEMBL

Q9R1R5

Conserved Domains (1) summary

cl25409
Location:1 → 179

SDR; Short-chain dehydrogenases/reductases (SDR)
NM_021557.6 → NP_067532.2 retinol dehydrogenase 11 isoform 1

See identical proteins and their annotated locations for NP_067532.2

Status: VALIDATED

Source sequence(s)

AK004413, AK135443, BU053368

Consensus CDS

CCDS36480.1

UniProtKB/Swiss-Prot

Q3UXM9, Q9D0U5, Q9QYF1

UniProtKB/TrEMBL

Q9R1R9

Related

ENSMUSP00000124066.2, ENSMUST00000161204.8

Conserved Domains (2) summary

PRK06197
Location:38 → 311

PRK06197; short chain dehydrogenase; Provisional

cl21454
Location:38 → 306

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins