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Meg3 maternally expressed 3 [ Mus musculus (house mouse) ]

Gene ID: 17263, updated on 25-Nov-2021

Summary

Official Symbol
Meg3provided by MGI
Official Full Name
maternally expressed 3provided by MGI
Primary source
MGI:MGI:1202886
See related
Ensembl:ENSMUSG00000021268
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtl2; R74756; R75394; AI425946; AW108224; D12Bwg1266e; 2900016C05Rik; 3110050O07Rik; 6330408G06Rik
Summary
This gene is paternally-imprinted and thus expressed predominantly from the maternal allele. It generates alternatively-spliced long non protein-coding RNAs that overlap with the microRNAs Mir770 and Mir1906-1. Transcripts from this gene function as negative regulators of growth and may be down-regulated in tumor cells. This gene is expressed in a reciprocal pattern from the nearby Dlk1 (delta-like 1 homolog) gene, which is paternally-expressed. Deletion of this locus disrupts imprinting in this genomic region and results in perinatal morbidity. [provided by RefSeq, Dec 2013]
Expression
Broad expression in limb E14.5 (RPKM 360.3), frontal lobe adult (RPKM 253.8) and 15 other tissues See more
Orthologs
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Genomic context

See Meg3 in Genome Data Viewer
Location:
12 F1; 12 60.25 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (109506879..109538163)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (109540996..109571729)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (110779206..110809939)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene delta like non-canonical Notch ligand 1 Neighboring gene predicted gene, 34081 Neighboring gene VISTA enhancer mm799 Neighboring gene predicted gene, 34017 Neighboring gene microRNA 1906-1 Neighboring gene microRNA 770 Neighboring gene retrotransposon Gaglike 1 Neighboring gene microRNA 673 Neighboring gene microRNA 493

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Other Names

  • GTL2, imprinted maternally expressed untranslated mRNA
  • gene trap locus 2
  • maternally expressed gene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003633.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks multiple 5' exons and differs in the 5' terminal exon, resulting in a longer transcript, compared to variant 2.
    Source sequence(s)
    AC152063, AK018105, AK147321, BE992865
  2. NR_027651.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents variant 2.
    Source sequence(s)
    AC152063, AK018105, AK147321, BC094421, BE992865, BY134134
  3. NR_027652.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate exon in the 5' region and differs in the 3' terminal exon, resulting in a shorter transcript, compared to variant 2.
    Source sequence(s)
    BC024818, BY134134, Y13832
    Related
    ENSMUST00000143836.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    109506879..109538163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144513.2: Suppressed sequence

    Description
    NM_144513.2: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
  2. NR_046475.1: Suppressed sequence

    Description
    NR_046475.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  3. NR_104450.1: Suppressed sequence

    Description
    NR_104450.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  4. NR_104451.1: Suppressed sequence

    Description
    NR_104451.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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