Mmp14 matrix metallopeptidase 14 (membrane-inserted) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mmp14provided by MGI
Official Full Name: matrix metallopeptidase 14 (membrane-inserted)provided by MGI
Primary source: MGI:MGI:101900
See related: Ensembl:ENSMUSG00000000957 AllianceGenome:MGI:101900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sabe; MMP-X1; MT1-MMP; MT-MMP-1
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]
Expression: Broad expression in ovary adult (RPKM 116.4), limb E14.5 (RPKM 100.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.79 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54669055..54679913)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54431598..54442456)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts.
Title: Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts.
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis.
Title: Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis.
MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism.
Title: MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism.
Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair.
Title: Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair.
Loss of Endothelial Cell Matrix Metalloproteinase 14 Reduces Melanoma Growth and Metastasis by Increasing Tumor Vessel Stability.
Title: Loss of Endothelial Cell Matrix Metalloproteinase 14 Reduces Melanoma Growth and Metastasis by Increasing Tumor Vessel Stability.
Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.
Title: Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.
Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension.
Title: Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension.
Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth.
Title: Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth.
Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.
Title: Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.
Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis.
Title: Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis.

Submit: New GeneRIF Correction See all GeneRIFs (118)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (13) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mmp14 (e-PCR), detects polymorphism
- UniSTS:143878

Mmp14 (e-PCR), detects polymorphism
- UniSTS:143879

Mmp14 (e-PCR), detects polymorphism
- UniSTS:527424

Mmp14 (e-PCR), detects polymorphism
- UniSTS:265620

AI325305 (e-PCR)
- UniSTS:180651

MMP14 (e-PCR)
- UniSTS:264111

MARC_9867-9868:996688667:1 (e-PCR)
- UniSTS:270019

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collagen catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within craniofacial suture morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endochondral ossification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within head development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ossification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue remodeling	ISO Inferred from Sequence Orthology more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zymogen activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zymogen activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in macropinosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: matrix metalloproteinase-14

Names: Membrane type 1-MMP; matrix metalloproteinase 14 (membrane-inserted); membrane-type-1 matrix metalloproteinase; type 1 matrix metalloprotease 14

NP_032634.3

EC 3.4.24.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008608.4 → NP_032634.3 matrix metalloproteinase-14 preproprotein

See identical proteins and their annotated locations for NP_032634.3

Status: REVIEWED

Source sequence(s)

AC206013, AK165014, W75261

Consensus CDS

CCDS36922.1

UniProtKB/Swiss-Prot

O08645, O35369, P53690, Q8BTX2

UniProtKB/TrEMBL

Q3TQH0

Related

ENSMUSP00000087119.5, ENSMUST00000089688.6

Conserved Domains (5) summary

cd00094
Location:316 → 508

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:118 → 284

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:118 → 284

Peptidase_M10; Matrixin

pfam01471
Location:36 → 88

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:560 → 582

DUF3377; Domain of unknown function (DUF3377)