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Mmp8 matrix metallopeptidase 8 [ Mus musculus (house mouse) ]

Gene ID: 17394, updated on 19-Sep-2021

Summary

Official Symbol
Mmp8provided by MGI
Official Full Name
matrix metallopeptidase 8provided by MGI
Primary source
MGI:MGI:1202395
See related
Ensembl:ENSMUSG00000005800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BB138268
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
Expression
Biased expression in liver E18 (RPKM 19.0) and liver E14.5 (RPKM 0.8) See more
Orthologs
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Genomic context

See Mmp8 in Genome Data Viewer
Location:
9; 9 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7558430..7568487)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7558429..7568486)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (7558429..7568486)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 1a (interstitial collagenase) Neighboring gene matrix metallopeptidase 10 Neighboring gene predicted gene, 31751 Neighboring gene matrix metallopeptidase 27 Neighboring gene matrix metallopeptidase 20 (enamelysin) Neighboring gene expressed sequence AV064505

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neutrophil collagenase
Names
collagenase-2
matrix metalloproteinase-8
NP_032637.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008611.4NP_032637.3  neutrophil collagenase preproprotein

    See identical proteins and their annotated locations for NP_032637.3

    Status: REVIEWED

    Source sequence(s)
    AK137468, BY204369, BY548872
    Consensus CDS
    CCDS22808.1
    UniProtKB/Swiss-Prot
    O70138
    Related
    ENSMUSP00000018765.3, ENSMUST00000018765.4
    Conserved Domains (4) summary
    cd00094
    Location:276464
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:107262
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:107262
    Peptidase_M10; Matrixin
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    7558430..7568487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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