Foxk1 forkhead box K1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxk1provided by MGI
Official Full Name: forkhead box K1provided by MGI
Primary source: MGI:MGI:1347488
See related: Ensembl:ENSMUSG00000056493 AllianceGenome:MGI:1347488
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mnf; Gm10868; A630048H08Rik
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell growth; negative regulation of transcription, DNA-templated; and positive regulation of transcription, DNA-templated. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and retina. Orthologous to human FOXK1 (forkhead box K1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 16.4), ovary adult (RPKM 12.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 81.53 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (142387252..142447770)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (142401497..142462015)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
Title: Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
FOXK1 regulates Wnt signalling to promote cardiogenesis.
Title: FOXK1 regulates Wnt signalling to promote cardiogenesis.
FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation.
Title: FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation.
The siRNA-mediated repression of vimentin in FOXK1-overexpressing cells reversed the epithelial-mesenchymal transition -like phenotype and reduced Gastric Cancer cell migration and invasion in vitro and in vivo.
Title: Coexpression of FOXK1 and vimentin promotes EMT, migration, and invasion in gastric cancer cells.
Knockdown of FoxK1 in primary hepatocytes decreased both glucose production and insulin's ability to suppress it. The findings expand the repertoire of insulin-dependent transcription factors and identify FoxK1 as a contributor to insulin signaling.
Title: Identification of Insulin-Responsive Transcription Factors That Regulate Glucose Production by Hepatocytes.
in vitro and in vivo experiments, including studies of primary human cells, show how FOXK1 and/or FOXK2 are likely to act as important regulators that reprogram cellular metabolism to induce aerobic glycolysis
Title: FOXK1 and FOXK2 regulate aerobic glycolysis.
FoxK1/K2 are reciprocally regulated to FoxO1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function.
Title: FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.
Foxk1 mediates mTORC1-driven metabolic rewiring, and it is likely to be critical for metabolic diseases where improper mTORC1 signaling plays an important role.
Title: mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.
Foxk1 and Foxk2 are identified as transcriptional repressors of autophagy in muscle cells and fibroblasts.
Title: Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.
in the developing eyes, Foxk1 protein is localized in bipolar, amacrine and ganglion cells with an onset of Foxk1 expression from E15 onwards; expression pattern during development suggests that Foxk1 may have an important role in retinal cells
Title: The transcription factor Foxk1 is expressed in developing and adult mouse neuroretina.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548378

AI463295 (e-PCR)
- UniSTS:185647

L26507 (e-PCR)
- UniSTS:163378

Foxk1 (e-PCR), detects polymorphism
- UniSTS:257074

Foxk1 (e-PCR), detects polymorphism
- UniSTS:257075

RH126273 (e-PCR)
- UniSTS:162981

Foxk1 (e-PCR), detects polymorphism
- UniSTS:536523

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of canonical glycolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein K1

Names: myocyte nuclear factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199068.2 → NP_951031.2 forkhead box protein K1

See identical proteins and their annotated locations for NP_951031.2

Status: VALIDATED

Source sequence(s)

AK147375, BB646926, BE690639, CB249706

Consensus CDS

CCDS19826.1

UniProtKB/Swiss-Prot

O35939, P42128, Q3UHI6, Q3UN67

Related

ENSMUSP00000072616.6, ENSMUST00000072837.7

Conserved Domains (3) summary

COG1716
Location:88 → 190

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:96 → 189

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam00250
Location:291 → 377

Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

142387252..142447770

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504654.2 → XP_006504717.1 forkhead box protein K1 isoform X1

Conserved Domains (1) summary

pfam00250
Location:120 → 206

Forkhead; Forkhead domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_010812.2: Suppressed sequence

Description

NM_010812.2: This RefSeq was permanently suppressed because there is insufficient support for the transcript and the protein.