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Grap2 GRB2-related adaptor protein 2 [ Mus musculus (house mouse) ]

Gene ID: 17444, updated on 5-Mar-2024

Summary

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Official Symbol
Grap2provided by MGI
Official Full Name
GRB2-related adaptor protein 2provided by MGI
Primary source
MGI:MGI:1333842
See related
Ensembl:ENSMUSG00000042351 AllianceGenome:MGI:1333842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P38; GRID; Gads; GrbX; GrpL; Mona; GRB2L; GRBLG; Grf40; GRAP-2
Summary
Predicted to be located in several cellular components, including cytosol; endosome; and nucleoplasm. Is expressed in brain; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human GRAP2 (GRB2 related adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 26.9), spleen adult (RPKM 12.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.88 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80456798..80537055)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80572597..80652854)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23220 Neighboring gene ENTH domain containing 1 Neighboring gene predicted gene, 19141 Neighboring gene STARR-seq mESC enhancer starr_39234 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:80402055-80402238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:80402767-80403020 Neighboring gene STARR-seq mESC enhancer starr_39235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:80460969-80461152 Neighboring gene STARR-positive B cell enhancer ABC_E942 Neighboring gene STARR-seq mESC enhancer starr_39236 Neighboring gene STARR-seq mESC enhancer starr_39237 Neighboring gene microRNA 6957 Neighboring gene RIKEN cDNA A430088P11 gene Neighboring gene STARR-positive B cell enhancer ABC_E608 Neighboring gene family with sequence similarity 83, member F Neighboring gene STARR-seq mESC enhancer starr_39239 Neighboring gene STARR-positive B cell enhancer ABC_E9421 Neighboring gene trinucleotide repeat containing 6b Neighboring gene STARR-seq mESC enhancer starr_39241 Neighboring gene STARR-positive B cell enhancer ABC_E7395 Neighboring gene STARR-seq mESC enhancer starr_39242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:80645405-80645514 Neighboring gene STARR-seq mESC enhancer starr_39245 Neighboring gene microRNA 5113

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of GADS enhances FLT3-induced mitogenic signaling. Chougule RA, et al. Oncotarget, 2016 Mar 22. PMID 26895103, Free PMC Article
  2. Gads regulates the expansion phase of CD8+ T cell-mediated immunity. Zhang EY, et al. J Immunol, 2011 Apr 15. PMID 21411729, Free PMC Article
  3. Gads-deficient thymocytes are blocked at the transitional single positive CD4+ stage. Dalheimer SL, et al. Eur J Immunol, 2009 May. PMID 19337995, Free PMC Article
  4. Gads-/- mice reveal functionally distinct subsets of TCRbeta+ CD4-CD8- double-negative thymocytes. Zeng L, et al. J Immunol, 2007 Jul 15. PMID 17617593
  5. Expression and function of the adaptor protein Gads in murine B cells. Yankee TM, et al. Eur J Immunol, 2005 Apr. PMID 15761845

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High GADS expression is associated with neoplasms.
    Title: Expression of GADS enhances FLT3-induced mitogenic signaling.
  2. The combined loss of Gads and CD127 reveals a novel function of Gads prior to T cell receptor beta expression
    Title: The combined loss of Gads and CD127 reveals a novel function of Gads prior to TCRβ expression.
  3. GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates.
    Title: Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia.
  4. Data show that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.
    Title: Gads regulates the expansion phase of CD8+ T cell-mediated immunity.
  5. Gads plays a key role in linking the adapter LAT to SLP-76 in response to weak activation of GPVI and CLEC-2 whereas LAT is required for full activation over a wider range of agonist concentrations.
    Title: Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.
  6. Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice
    Title: Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice.
  7. Results reveal the basis for preferential recognition of specific LAT sites by Gads.
    Title: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.
  8. Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
    Title: Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix.
  9. Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. (Gab3 scaffolding protein)
    Title: Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.
  10. The Gads adaptor protein is critical for homeostasis of CD4(+) T cells.
    Title: The Gads (GrpL) adaptor protein regulates T cell homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GRB2-related adaptor protein 2
Names
GRB-2-like protein
GRB-2-related monocytic adapter protein
Grb2-related adaptor downstream of Sch
adapter protein GRID
growth factor receptor-binding protein
hematopoietic cell-associated adaptor protein GrpL
monocytic adapter
monocytic adaptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289442.1 → NP_001276371.1  GRB2-related adaptor protein 2

    See identical proteins and their annotated locations for NP_001276371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC147041, BC052496
    Consensus CDS
    CCDS27663.1
    UniProtKB/Swiss-Prot
    O89100
    UniProtKB/TrEMBL
    Q3U0E8
    Related
    ENSMUSP00000155681.2, ENSMUST00000229980.2
    Conserved Domains (3) summary
    cd09941
    Location:54 → 147
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11950
    Location:267 → 319
    SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    cl17036
    Location:2 → 53
    SH3; Src Homology 3 domain superfamily

  2. NM_010815.3 → NP_034945.1  GRB2-related adaptor protein 2

    See identical proteins and their annotated locations for NP_034945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC147041
    Consensus CDS
    CCDS27663.1
    UniProtKB/Swiss-Prot
    O89100
    UniProtKB/TrEMBL
    Q3U0E8
    Related
    ENSMUSP00000046532.8, ENSMUST00000043149.9
    Conserved Domains (3) summary
    cd09941
    Location:54 → 147
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11950
    Location:267 → 319
    SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    cl17036
    Location:2 → 53
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    80456798..80537055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89100.1 GenPept UniProtKB/Swiss-Prot:O89100

Gene LinkOut

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