daf-7 Dauer larva development regulatory growth factor daf-7 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: daf-7
Gene description: Dauer larva development regulatory growth factor daf-7
Primary source: WormBase:WBGene00000903
Locus tag: CELE_B0412.2
See related: AllianceGenome:WB:WBGene00000903
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cytokine activity and transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to cGMP; regulation of gene expression; and response to bacterium. Located in extracellular space. Is expressed in coelomocyte; neurons; pharynx; and in male. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; artery disease (multiple); colorectal cancer (multiple); and lung disease (multiple). Orthologous to several human genes including GDF11 (growth differentiation factor 11) and MSTN (myostatin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (811844..813773)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming growth factor-beta DAF-7 protein in Caenorhabditis elegans.
Title: The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming growth factor-β DAF-7 protein in Caenorhabditis elegans.
Dauer Formation in C. elegans Is Modulated through AWC and ASI-Dependent Chemosensation.
Title: Dauer Formation in C. elegans Is Modulated through AWC and ASI-Dependent Chemosensation.
Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans.
Title: Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans.
DAF-7, which is secreted in part from a specific pair of ciliated neurons, acts as a systemic factor that activates a canonical TGFbeta signaling pathway in distant tissues to induce autophagy
Title: TGFβ-like DAF-7 acts as a systemic signal for autophagy regulation in C. elegans.
The authors show that the interactions between daf-7 and tph-1 regulate redundancy and synergy among neurons in food encoding through coordinated control of circuit-level signal and noise properties.
Title: Genetic control of encoding strategy in a food-sensing neural circuit.
blmp-1 is necessary for controlling histone methylation level in daf-7 mutants, suggesting BLMP-1 regulates the expression of SAMS-1, which in turn may regulate histone methylation and dauer formation.Our results reveal a new interaction between BLMP-1/BLIMP-1 and LIN-40/MTA1, as well as potential epigenetic downstream pathways
Title: BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans.
DAF-7 expression decreases as animals age during adulthood. Age-dependent diminished expression contributes to the reduced sensitivity of aging animals to the effects of dietary restriction.
Title: Age-Dependent Neuroendocrine Signaling from Sensory Neurons Modulates the Effect of Dietary Restriction on Longevity of Caenorhabditis elegans.
Using functional, fluorescently-tagged protein, we find that, in animals with mutant DAF-28/IGF, the wild-type DAF-7/TGF-beta is mislocalized to and accumulates in the proximal axon of the ASI neuron. Activation of two different branches of the unfolded protein response can modulate both the developmental phenotype and DAF-7 mislocalization in DAF-28(R37C) animals, but appear to act through divergent mechanisms
Title: A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.
GLR-1 protein and glr-1 transcription are increased in neurons of DAF-7 mutants.
Title: The DAF-7/TGF-β signaling pathway regulates abundance of the Caenorhabditis elegans glutamate receptor GLR-1.
A gene-expression-based neural code for food abundance that modulates lifespan includes daf-7 that primarily regulates gene-expression variability, while tph-1 primarily regulates the dynamic range of gene-expression responses.
Title: A gene-expression-based neural code for food abundance that modulates lifespan.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0412.2 (e-PCR)
- UniSTS:308383

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cGMP	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to pheromone	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of molecule of bacterial origin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dauer entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of eating behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Dauer larva development regulatory growth factor daf-7

NP_497265.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

811844..813773

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064864.6 → NP_497265.1 Dauer larva development regulatory growth factor daf-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497265.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P92172

Conserved Domains (1) summary

smart00204
Location:250 → 350

TGFB; Transforming growth factor-beta (TGF-beta) family