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gab-1 Gamma-aminobutyric acid receptor subunit beta [ Caenorhabditis elegans ]

Gene ID: 176691, updated on 11-Apr-2024

Summary

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Gene symbol
gab-1
Gene description
Gamma-aminobutyric acid receptor subunit beta
Primary source
WormBase:WBGene00001512
Locus tag
CELE_ZC482.1
See related
AllianceGenome:WB:WBGene00001512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GABA-A receptor activity and extracellular ligand-gated ion channel activity. Involved in ion transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in body wall musculature and neurons. Human ortholog(s) of this gene implicated in autistic disorder; childhood absence epilepsy; developmental and epileptic encephalopathy 43; developmental and epileptic encephalopathy 45; and developmental and epileptic encephalopathy 92. Orthologous to several human genes including GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1) and GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (12771868..12779726, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Insulin/EGF-Receptor L Domain protein Neighboring gene pseudo Neighboring gene Ligand-Gated ion Channel Neighboring gene RING-type domain-containing protein Neighboring gene Alkylglycerol monooxygenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin. Feng XP, et al. J Neurochem, 2002 Nov. PMID 12421359
  2. Parental and larval exposure to nicotine modulate spontaneous activity as well as cholinergic and GABA receptor expression in adult C. elegans. Rose JK, et al. Neurotoxicol Teratol, 2013 Sep-Oct. PMID 23906944
  3. The genetics of ivermectin resistance in Caenorhabditis elegans. Dent JA, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10716995, Free PMC Article
  4. A new gene-finding tool: using the Caenorhabditis elegans operons for identifying functional partner proteins in human cells. Eichmüller S, et al. J Biol Chem, 2004 Feb 20. PMID 14615488
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-A receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GABA-A receptor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IC
Inferred by Curator
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Gamma-aminobutyric acid receptor subunit beta
NP_499661.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12771868..12779726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067260.5 → NP_499661.2  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499661.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18276, Q8ITG2
    Conserved Domains (3) summary
    TIGR00860
    Location:67 → 545
    LIC; Cation transporter family protein
    pfam02931
    Location:68 → 259
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:268 → 542
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18276.3

Gene LinkOut

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