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scav-2 SCAVenger receptor (CD36 family) related [ Caenorhabditis elegans ]

Gene ID: 176787, updated on 23-Nov-2023

Summary

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Gene symbol
scav-2
Gene description
SCAVenger receptor (CD36 family) related
Primary source
WormBase:WBGene00013578
Locus tag
CELE_Y76A2B.6
See related
AllianceGenome:WB:WBGene00013578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable scavenger receptor activity. Predicted to be involved in endocytosis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Is expressed in reproductive system. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; progressive myoclonus epilepsy 4; and pulmonary tuberculosis. Orthologous to human CD36 (CD36 molecule); SCARB1 (scavenger receptor class B member 1); and SCARB2 (scavenger receptor class B member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (13550601..13555334, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial Neighboring gene F-box associated domain-containing protein Neighboring gene Fructose-bisphosphate aldolase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. Means TK, et al. J Exp Med, 2009 Mar 16. PMID 19237602, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SCAVenger receptor (CD36 family) related
NP_499802.3
  • Confirmed by transcript evidence;
    Product from WormBase gene class scav

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13550601..13555334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067401.7 → NP_499802.3  SCAVenger receptor (CD36 family) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499802.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBM7
    Conserved Domains (1) summary
    pfam01130
    Location:46 → 505
    CD36; CD36 family
Nucleotide Protein
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