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cul-2 Cullin-2 [ Caenorhabditis elegans ]

Gene ID: 176806, updated on 25-Nov-2021

Summary

Gene symbol
cul-2
Gene description
Cullin-2
Primary source
WormBase:WBGene00000837
Locus tag
CELE_ZK520.4
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
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Genomic context

See cul-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (13687269..13692683)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Aquaporin Neighboring gene WD repeat-containing protein dyf-2 Neighboring gene Systemic RNA interference defective protein 2 Neighboring gene Peptidyl-prolyl cis-trans isomerase 2 Neighboring gene Serine/threonine kinase NLK Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterior/posterior axis specification, embryo IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
involved_in germ-line stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male germ-line sex determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male somatic sex determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of metaphase/anaphase transition of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription factor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Cullin-2
NP_001023007.1
  • Confirmed by transcript evidence
NP_001023008.1
  • Confirmed by transcript evidence
NP_001367020.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13687269..13692683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027836.6NP_001023007.1  Cullin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023007.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17390
    Conserved Domains (3) summary
    smart00182
    Location:441599
    CULLIN; Cullin
    smart00884
    Location:702767
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:17645
    Cullin; Cullin family
  2. NM_001027837.3NP_001023008.1  Cullin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023008.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17390
    Conserved Domains (2) summary
    smart00884
    Location:719784
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:32662
    Cullin; Cullin family
  3. NM_001379988.2NP_001367020.1  Cullin-2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    pfam00888
    Location:15612
    Cullin; Cullin family
    pfam10557
    Location:674735
    Cullin_Nedd8; Cullin protein neddylation domain
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