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aass-1 Saccharopine dehydrogenase [ Caenorhabditis elegans ]

Gene ID: 176842, updated on 11-Apr-2024

Summary

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Gene symbol
aass-1
Gene description
Saccharopine dehydrogenase
Primary source
WormBase:WBGene00019819
Locus tag
CELE_R02D3.1
See related
AllianceGenome:WB:WBGene00019819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable saccharopine dehydrogenase activity. Predicted to be involved in lysine biosynthetic process via aminoadipic acid. Predicted to be active in cytoplasm. Is expressed in gonadal sheath cell and hypodermal cell. Human ortholog(s) of this gene implicated in hyperlysinemia. Orthologous to human AASS (aminoadipate-semialdehyde synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See aass-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (245143..251925)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene EOG090X08PK Neighboring gene Conserved oligomeric Golgi complex subunit 8 Neighboring gene Ground-like domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Exonuclease domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. Zhou J, et al. J Cell Biol, 2019 Feb 4. PMID 30573525, Free PMC Article
  2. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables saccharopine dehydrogenase (NADP+, L-lysine-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables saccharopine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via aminoadipic acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Saccharopine dehydrogenase
NP_001294658.1
  • Confirmed by transcript evidence
NP_499884.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    245143..251925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307729.4 → NP_001294658.1  Saccharopine dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294658.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PFH6
    Conserved Domains (4) summary
    PLN02819
    Location:28 → 943
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
    cd12189
    Location:31 → 489
    LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
    pfam03435
    Location:511 → 626
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
    pfam16653
    Location:630 → 942
    Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain

  2. NM_067483.6 → NP_499884.1  Saccharopine dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499884.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44503
    Conserved Domains (4) summary
    PLN02819
    Location:28 → 925
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
    cd12189
    Location:31 → 471
    LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
    pfam03435
    Location:493 → 608
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
    pfam16653
    Location:612 → 924
    Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain
Nucleotide Protein
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