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manf-1 Mesencephalic astrocyte-derived neurotrophic factor homolog [ Caenorhabditis elegans ]

Gene ID: 177074, updated on 23-Nov-2023

Summary

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Gene symbol
manf-1
Gene description
Mesencephalic astrocyte-derived neurotrophic factor homolog
Primary source
WormBase:WBGene00021888
Locus tag
CELE_Y54G2A.23
See related
AllianceGenome:WB:WBGene00021888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables sulfatide binding activity. Involved in developmental growth; negative regulation of neuron death; and regulation of response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen and extracellular region. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in several structures, including anus; excretory gland cell; pharynx; rectal valve cell; and somatic cell. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to several human genes including MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (2927517..2928421, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene F-box C protein Neighboring gene Ubiquitin-conjugating enzyme E2 13 Neighboring gene Molybdate-anion transporter Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans MANF Homolog Is Necessary for the Protection of Dopaminergic Neurons and ER Unfolded Protein Response. Richman C, et al. Front Neurosci, 2018. PMID 30147641, Free PMC Article
  2. MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa. Hartman JH, et al. Eur J Cell Biol, 2019 Dec. PMID 31138438, Free PMC Article
  3. Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection. Bai M, et al. Nat Commun, 2018 Mar 1. PMID 29497057, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death.
    Title: Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfatide binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATF6-mediated unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dopaminergic neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Mesencephalic astrocyte-derived neurotrophic factor homolog
NP_500273.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2927517..2928421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067872.9 → NP_500273.2  Mesencephalic astrocyte-derived neurotrophic factor homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500273.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N3B0
    Conserved Domains (1) summary
    pfam10208
    Location:21 → 165
    Armet; Degradation arginine-rich protein for mis-folding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N3B0.2

Gene LinkOut

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