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mt-Co1 cytochrome c oxidase I, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17708, updated on 24-Apr-2022

Summary

Official Symbol
mt-Co1provided by MGI
Official Full Name
cytochrome c oxidase I, mitochondrialprovided by MGI
Primary source
MGI:MGI:102504
See related
AllianceGenome:MGI:102504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus (strain: C57BL/6J)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CoxI; COX1
Summary
Enables cytochrome-c oxidase activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, cytochrome c to oxygen; and response to oxidative stress. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including brown fat; heart; liver; metanephros; and skeletal muscle. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See mt-Co1 in Genome Data Viewer
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (5328..6872)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (5328..6872)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) MT (non-nuclear) NC_005089.1 (5328..6872)

Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene tRNA-Cys Neighboring gene tRNA-Tyr Neighboring gene tRNA-Ser Neighboring gene tRNA-Asp Neighboring gene cytochrome c oxidase subunit II

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the COX1 gene: The COX1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, and frog.
  • Orthologs
  • COI; CCOI

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytochrome-c oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in electron transport coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial respiratory chain complex IV IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 
part_of respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
 

General protein information

Names
cytochrome c oxidase subunit I
NP_904330.1
  • cytochrome oxidase subunit 1; cytochrome c oxidase polypeptide 1; cytochrome c oxidase subunit 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005089.1 Reference assembly

    Range
    5328..6872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_904330.1 cytochrome c oxidase subunit I (mitochondrion) [Mus musculus]

    See identical proteins and their annotated locations for NP_904330.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P00397
    UniProtKB/TrEMBL
    Q9MD68
    Related
    ENSMUSP00000080993.1
    Conserved Domains (1) summary
    MTH00153
    Location:4507
    COX1; cytochrome c oxidase subunit I; Provisional