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mt-Co2 cytochrome c oxidase II, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17709, updated on 24-Apr-2022

Summary

Official Symbol
mt-Co2provided by MGI
Official Full Name
cytochrome c oxidase II, mitochondrialprovided by MGI
Primary source
MGI:MGI:102503
See related
AllianceGenome:MGI:102503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus (strain: C57BL/6J)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COX2
Summary
Predicted to enable copper ion binding activity and oxidoreductase activity. Predicted to contribute to cytochrome-c oxidase activity. Predicted to be involved in ATP synthesis coupled electron transport; positive regulation of cellular biosynthetic process; and positive regulation of necrotic cell death. Located in mitochondrion. Is expressed in embryo; epiblast; heart; liver; and metanephros. Orthologous to several human genes including MTCO2P12 (MT-CO2 pseudogene 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See mt-Co2 in Genome Data Viewer
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (7013..7696)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (7013..7696)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) MT (non-nuclear) NC_005089.1 (7013..7696)

Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit I Neighboring gene tRNA-Ser Neighboring gene tRNA-Asp Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 8 Neighboring gene ATP synthase F0 subunit 6

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the COX2 gene: The COX2 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, rice, and frog.
  • Orthologs
  • COII; COXII

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 
part_of respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
 

General protein information

Names
cytochrome c oxidase subunit II
NP_904331.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005089.1 Reference assembly

    Range
    7013..7696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_904331.1 cytochrome c oxidase subunit II (mitochondrion) [Mus musculus]

    See identical proteins and their annotated locations for NP_904331.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P00405
    UniProtKB/TrEMBL
    Q7JCZ1
    Related
    ENSMUSP00000080994.1
    Conserved Domains (1) summary
    MTH00098
    Location:1227
    COX2; cytochrome c oxidase subunit II; Validated