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Polr2k polymerase (RNA) II (DNA directed) polypeptide K [ Mus musculus (house mouse) ]

Gene ID: 17749, updated on 5-Mar-2024

Summary

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Official Symbol
Polr2kprovided by MGI
Official Full Name
polymerase (RNA) II (DNA directed) polypeptide Kprovided by MGI
Primary source
MGI:MGI:102725
See related
Ensembl:ENSMUSG00000045996 AllianceGenome:MGI:102725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MafY; Mt1a; RPB12; RPABC4; RPB7.0; RPB10alpha; ABC10-alpha
Summary
Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and zinc ion binding activity. Acts upstream of or within transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in several structures, including cerebral cortex; nose; submandibular gland primordium; thymus primordium; and tooth. Orthologous to human POLR2K (RNA polymerase II, I and III subunit K). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 21.0), liver E14 (RPKM 19.6) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.1; 15 14.46 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36174156..36177158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36174010..36177012)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signalling 22 Neighboring gene STARR-seq mESC enhancer starr_38352 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene Neighboring gene F-box protein 43 Neighboring gene predicted gene, 22979 Neighboring gene sperm associated antigen 1 Neighboring gene predicted gene, 23754 Neighboring gene predicted gene, 41293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Penkowa M, et al. Glia, 2003 May. PMID 12673834
  2. Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter. Remondelli P, et al. Biochem J, 1997 Apr 1. PMID 9173905, Free PMC Article
  3. cDNA cloning of a mouse factor that activates transcription from a metal response element of the mouse metallothionein-I gene in yeast. Xu C. DNA Cell Biol, 1993 Jul-Aug. PMID 8329119
  4. Importin α7 is essential for zygotic genome activation and early mouse development. Rother F, et al. PLoS One, 2011 Mar 29. PMID 21479251, Free PMC Article
  5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metallothionein-I was upregulated by a cryolesion to a higher extent in GFAP-IL-6 transgenic mice, suggesting that it could be related to the neuroprotection afforded by the transgenic expression of IL-6.
    Title: Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Names
metallothionein-I gene transcription activator
NP_001034457.1
NP_075616.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039368.2 → NP_001034457.1  DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform a

    See identical proteins and their annotated locations for NP_001034457.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK008136, BY646564, CR516049
    Consensus CDS
    CCDS27426.1
    UniProtKB/TrEMBL
    Q8BFX0
    Related
    ENSMUSP00000051968.6, ENSMUST00000057177.7
    Conserved Domains (1) summary
    smart00659
    Location:56 → 99
    RPOLCX; RNA polymerase subunit CX

  2. NM_023127.3 → NP_075616.2  DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform b

    See identical proteins and their annotated locations for NP_075616.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK003023, AK008136, BY646564, CR516049
    Consensus CDS
    CCDS56980.1
    UniProtKB/Swiss-Prot
    Q63871
    UniProtKB/TrEMBL
    Q545V5, Q9D2S5
    Related
    ENSMUSP00000136975.2, ENSMUST00000180159.8
    Conserved Domains (1) summary
    smart00659
    Location:15 → 58
    RPOLCX; RNA polymerase subunit CX

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    36174156..36177158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63871.2 GenPept UniProtKB/Swiss-Prot:Q63871

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