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Mt3 metallothionein 3 [ Mus musculus (house mouse) ]

Gene ID: 17751, updated on 23-Jun-2021

Summary

Official Symbol
Mt3provided by MGI
Official Full Name
metallothionein 3provided by MGI
Primary source
MGI:MGI:97173
See related
Ensembl:ENSMUSG00000031760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mt-3
Expression
Biased expression in frontal lobe adult (RPKM 335.8), cortex adult (RPKM 298.1) and 4 other tissues See more
Orthologs
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Genomic context

See Mt3 in Genome Data Viewer
Location:
8 C5; 8 46.29 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94879235..94880776)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94152607..94154148)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (96676507..96678048)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39226 Neighboring gene metallothionein 4 Neighboring gene predicted gene, 39227 Neighboring gene metallothionein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadmium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IC
Inferred by Curator
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cadmium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cadmium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular metal ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular zinc ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in energy reserve metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone modification ISO
Inferred from Sequence Orthology
more info
 
involved_in leptin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lysosomal membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oxygen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of response to food IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in astrocyte end-foot ISO
Inferred from Sequence Orthology
more info
 
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metallothionein-3
Names
GIF
MT-III
growth inhibitory factor
metallothionein-III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013603.2NP_038631.1  metallothionein-3

    See identical proteins and their annotated locations for NP_038631.1

    Status: VALIDATED

    Source sequence(s)
    AC131733, AK140209
    Consensus CDS
    CCDS40436.1
    UniProtKB/Swiss-Prot
    P28184
    UniProtKB/TrEMBL
    Q3USP9
    Related
    ENSMUSP00000034211.9, ENSMUST00000034211.10
    Conserved Domains (1) summary
    pfam00131
    Location:168
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94879235..94880776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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