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egl-21 Carboxypeptidase E [ Caenorhabditis elegans ]

Gene ID: 177940, updated on 6-Jul-2021

Summary

Gene symbol
egl-21
Gene description
Carboxypeptidase E
Primary source
WormBase:WBGene00001189
Locus tag
CELE_F01D4.4
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
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Genomic context

See egl-21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (10478442..10481844, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Glucuronosyltransferase Neighboring gene B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog Neighboring gene pseudo Neighboring gene PHD-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Serine/threonine-protein phosphatase 2B catalytic subunit

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to carbon dioxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuropeptide processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of acetylcholine secretion, neurotransmission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of defecation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of defecation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of digestive system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Carboxypeptidase E
NP_501935.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10478442..10481844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069534.7NP_501935.1  Carboxypeptidase E [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501935.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17754
    Conserved Domains (2) summary
    cd03858
    Location:40358
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:362446
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
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