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Fam89b family with sequence similarity 89, member B [ Mus musculus (house mouse) ]

Gene ID: 17826, updated on 5-Mar-2024

Summary

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Official Symbol
Fam89bprovided by MGI
Official Full Name
family with sequence similarity 89, member Bprovided by MGI
Primary source
MGI:MGI:106595
See related
Ensembl:ENSMUSG00000024939 AllianceGenome:MGI:106595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMTV; Mtvr2; 1110021A21Rik
Summary
Enables transcription corepressor binding activity. Involved in establishment of cell polarity; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of cell migration. Located in cytoplasm and lamellipodium. Is expressed in several structures, including branchial arch; cranial ganglion; heart valve; medulla oblongata basal plate mantle layer; and sensory organ. Orthologous to human FAM89B (family with sequence similarity 89 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 186.5), ovary adult (RPKM 160.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.34 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5778115..5779694, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5728087..5729666, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 3 Neighboring gene STARR-positive B cell enhancer ABC_E4259 Neighboring gene STARR-positive B cell enhancer ABC_E11012 Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene potassium channel, subfamily K, member 7 Neighboring gene EH domain binding protein 1-like 1 Neighboring gene zinc ribbon domain containing 2 Neighboring gene latent transforming growth factor beta binding protein 3 Neighboring gene SCY1-like 1 (S. cerevisiae)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential. Cordero A, et al. J Mammary Gland Biol Neoplasia, 2023 Feb 18. PMID 36808257, Free PMC Article
  2. The Ski-binding protein C184M negatively regulates tumor growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm. Kokura K, et al. J Biol Chem, 2003 May 30. PMID 12646588
  3. Identification of human homologues of the mouse mammary tumor virus receptor. Stewart AF. Arch Virol, 2002 Mar. PMID 11958456
  4. Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. Sakuma-Takagi M, et al. Biochem Biophys Res Commun, 1999 Oct 5. PMID 10512749
  5. A novel membrane protein is a mouse mammary tumor virus receptor. Golovkina TV, et al. J Virol, 1998 Apr. PMID 9525630, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential.
    Title: Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential.
Submit: New GeneRIF Correction

General gene information

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Markers

Potential readthrough

Included gene: Znrd2

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine repeat adapter protein 25
Names
C184L ORF2 protein
C184M protein
MMTV receptor
mammary tumor virus receptor 2
protein FAM89B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023166.2 → NP_075655.2  leucine repeat adapter protein 25 isoform 2

    See identical proteins and their annotated locations for NP_075655.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC056166, CJ132526
    Consensus CDS
    CCDS50361.1
    UniProtKB/TrEMBL
    Q7TMI7
    Related
    ENSMUSP00000124294.2, ENSMUST00000161368.2

  2. NM_181452.2 → NP_852117.2  leucine repeat adapter protein 25 isoform 1

    See identical proteins and their annotated locations for NP_852117.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC056166, BM942073, CJ132526
    Consensus CDS
    CCDS37890.1
    UniProtKB/Swiss-Prot
    Q8K2S5, Q9JHD8, Q9JL54, Q9QUI1
    Related
    ENSMUSP00000097538.4, ENSMUST00000099955.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5778115..5779694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUI1.1 GenPept UniProtKB/Swiss-Prot:Q9QUI1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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