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Mug2 murinoglobulin 2 [ Mus musculus (house mouse) ]

Gene ID: 17837, updated on 23-Jun-2021

Summary

Official Symbol
Mug2provided by MGI
Official Full Name
murinoglobulin 2provided by MGI
Primary source
MGI:MGI:99836
See related
Ensembl:ENSMUSG00000030131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpamd8
Expression
Restricted expression toward liver adult (RPKM 83.2) See more
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Genomic context

See Mug2 in Genome Data Viewer
Location:
6; 6 F1
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (121983688..122062927)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122006729..122085968)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (121956816..122035985)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 44173 Neighboring gene murinoglobulin 4, pseudogene Neighboring gene thymosin beta-10 pseudogene Neighboring gene murinoglobulin pseudogene Neighboring gene murinoglobulin, pseudogene 1 Neighboring gene predicted gene, 46974

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
murinoglobulin-2
Names
C3 and PZP-like, alpha-2-macroglobulin domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008646.3NP_032672.2  murinoglobulin-2 precursor

    See identical proteins and their annotated locations for NP_032672.2

    Status: VALIDATED

    Source sequence(s)
    AC153582, AC153838, AC156279
    Consensus CDS
    CCDS39619.1
    UniProtKB/Swiss-Prot
    P28666
    Related
    ENSMUSP00000080469.7, ENSMUST00000081777.8
    Conserved Domains (7) summary
    COG2373
    Location:961075
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:9601241
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:740830
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129221
    A2M_N; MG2 domain
    pfam07677
    Location:13531440
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10131243
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:459598
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    121983688..122062927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505699.2XP_006505762.1  murinoglobulin-2 isoform X1

    Conserved Domains (7) summary
    cd02897
    Location:9601266
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:740830
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:13781465
    A2M_recep; A-macroglobulin receptor
    pfam17789
    Location:340434
    MG4; Macroglobulin domain MG4
    pfam17791
    Location:223299
    MG3; Macroglobulin domain MG3
    pfam01835
    Location:129221
    A2M_N; MG2 domain
    pfam07703
    Location:459599
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
  2. XM_006505700.2XP_006505763.1  murinoglobulin-2 isoform X2

    Conserved Domains (7) summary
    cd02897
    Location:9601266
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:740830
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:13781465
    A2M_recep; A-macroglobulin receptor
    pfam17789
    Location:340434
    MG4; Macroglobulin domain MG4
    pfam17791
    Location:223299
    MG3; Macroglobulin domain MG3
    pfam01835
    Location:129221
    A2M_N; MG2 domain
    pfam07703
    Location:459599
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
  3. XM_006505701.2XP_006505764.1  murinoglobulin-2 isoform X3

    Conserved Domains (7) summary
    cd02897
    Location:9601241
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:740830
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:13531440
    A2M_recep; A-macroglobulin receptor
    pfam17789
    Location:340434
    MG4; Macroglobulin domain MG4
    pfam17791
    Location:223299
    MG3; Macroglobulin domain MG3
    pfam01835
    Location:129221
    A2M_N; MG2 domain
    pfam07703
    Location:459599
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
  4. XM_006505702.1XP_006505765.1  murinoglobulin-2 isoform X4

    Conserved Domains (6) summary
    cd02897
    Location:8461152
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:626716
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:12641351
    A2M_recep; A-macroglobulin receptor
    pfam17789
    Location:226320
    MG4; Macroglobulin domain MG4
    pfam07703
    Location:345485
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl19929
    Location:129161
    A2M_N; MG2 domain
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