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ife-3 Eukaryotic translation initiation factor 4E-3 [ Caenorhabditis elegans ]

Gene ID: 178536, updated on 23-Nov-2023

Summary

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Gene symbol
ife-3
Gene description
Eukaryotic translation initiation factor 4E-3
Primary source
WormBase:WBGene00002061
Locus tag
CELE_B0348.6
See related
AllianceGenome:WB:WBGene00002061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA 7-methylguanosine cap binding activity. Involved in embryo development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in Z2; Z3; germ line; gonad; and oocyte. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ife-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (6584..7828, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Intrinsically Disordered Protein, expressed in Pharynx Neighboring gene Secreted protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation. Liu W, et al. Nucleic Acids Res, 2011 Nov 1. PMID 21965542, Free PMC Article
  2. The canonical eIF4E isoform of C. elegans regulates growth, embryogenesis, and germline sex-determination. Mangio RS, et al. Biol Open, 2015 May 15. PMID 25979704, Free PMC Article
  3. Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap. Ruszczyńska-Bartnik K, et al. J Mol Model, 2011 Apr. PMID 20535623, Free PMC Article
  4. The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs. Wallace A, et al. Mol Cell Biol, 2010 Apr. PMID 20154140, Free PMC Article
  5. Turnip mosaic virus genome-linked protein VPg binds C-terminal region of cap-bound initiation factor 4E orthologue without exhibiting host cellular specificity. Okade H, et al. J Biochem, 2009 Mar. PMID 19122207, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that mRNA 5' untranslated regions affect translation initiation through interaction with eIF4E/G in nematodes and raise the issue of whether eIF4E/G-RNA interactions play a role in the translation of other eukaryotic mRNAs.
    Title: The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA 7-methylguanosine cap binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Eukaryotic translation initiation factor 4E-3
NP_503123.1
  • Confirmed by transcript evidence
NP_503124.1
  • Confirmed by transcript evidence
NP_741502.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6584..7828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171920.6 → NP_741502.1  Eukaryotic translation initiation factor 4E-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741502.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61955
    Conserved Domains (1) summary
    pfam01652
    Location:36 → 194
    IF4E; Eukaryotic initiation factor 4E

  2. NM_070722.6 → NP_503123.1  Eukaryotic translation initiation factor 4E-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503123.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61955, Q8MNX5, Q95X31
    Conserved Domains (1) summary
    pfam01652
    Location:36 → 195
    IF4E; Eukaryotic initiation factor 4E

  3. NM_070723.8 → NP_503124.1  Eukaryotic translation initiation factor 4E-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503124.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61955
    Conserved Domains (1) summary
    pfam01652
    Location:36 → 192
    IF4E; Eukaryotic initiation factor 4E
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O61955.2

Gene LinkOut

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