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Mybl2 myeloblastosis oncogene-like 2 [ Mus musculus (house mouse) ]

Gene ID: 17865, updated on 21-Apr-2024

Summary

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Official Symbol
Mybl2provided by MGI
Official Full Name
myeloblastosis oncogene-like 2provided by MGI
Primary source
MGI:MGI:101785
See related
Ensembl:ENSMUSG00000017861 AllianceGenome:MGI:101785
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmyb; B-Myb
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and mitotic spindle assembly. Located in nucleus. Part of Myb complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and skin. Used to study acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 17.0), liver E14 (RPKM 15.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H2; 2 84.0 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162896246..162926608)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163054327..163084688)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serum/glucocorticoid regulated kinase 2 Neighboring gene STARR-seq mESC enhancer starr_06293 Neighboring gene intraflagellar transport 52 Neighboring gene STARR-seq mESC enhancer starr_06295 Neighboring gene STARR-positive B cell enhancer ABC_E6013 Neighboring gene STARR-seq mESC enhancer starr_06298 Neighboring gene microRNA 7003 Neighboring gene gametocyte specific factor 1-like Neighboring gene predicted gene 11454

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells. Zhou Z, et al. Cell Prolif, 2017 Apr. PMID 27878894, Free PMC Article
  2. B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. Baker SJ, et al. Proc Natl Acad Sci U S A, 2014 Feb 25. PMID 24516162, Free PMC Article
  3. The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells. Zhan M, et al. PLoS One, 2012. PMID 22936984, Free PMC Article
  4. Generation of a conditional allele of the B-myb gene. García P, et al. Genesis, 2005 Dec. PMID 16283626
  5. A B-myb promoter corepressor site facilitates in vivo occupation of the adjacent E2F site by p107 x E2F and p130 x E2F complexes. Catchpole S, et al. J Biol Chem, 2002 Oct 11. PMID 12147683

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.
    Title: Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.
  2. Protein-protein interaction studies showed that YAP binds directly to B-MYB, a subunit of MMB, in a manner dependent on the YAP WW domains and a PPXY motif in B-MYB. Disruption of the interaction by overexpression of the YAP binding domain of B-MYB strongly inhibits the proliferation of cardiomyocytes.
    Title: Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes.
  3. Downregulation of B-myb induced senescence by upregulation of p22(phox) and activation of the ROS/p53/p21 pathway
    Title: Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
  4. B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.
    Title: B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.
  5. MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.
    Title: MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.
  6. Results coupled with functional studies demonstrate that B-MYB not only controls and accelerates cell cycle progression in ESCs it contributes to fate decisions and maintenance of pluripotent stem cell identity.
    Title: The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells.
  7. Our data suggest that B-Myb is required as a pioneer factor to enable FoxM1 binding to G2/M gene promoters and explains how these transcription factors may collaborate to induce mitosis.
    Title: Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb.
  8. Mybl2 upregulation induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression.
    Title: Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
  9. Lin-9 and B-Myb were both required for transcription of G(2)/M genes such as Cyclin B1 and Survivin.
    Title: A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells.
  10. proliferation-inhibiting A(2B)AR is itself an inducible receptor regulated by B-Myb.
    Title: B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic spindle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Myb complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myb-related protein B
Names
myb-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008652.2 → NP_032678.1  myb-related protein B

    See identical proteins and their annotated locations for NP_032678.1

    Status: PROVISIONAL

    Source sequence(s)
    AK028497
    Consensus CDS
    CCDS17006.1
    UniProtKB/Swiss-Prot
    P48972
    Related
    ENSMUSP00000018005.4, ENSMUST00000018005.10
    Conserved Domains (4) summary
    smart00717
    Location:83 → 131
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:83 → 129
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam09316
    Location:454 → 599
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:34 → 94
    Myb_DNA-bind_6; Myb-like DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    162896246..162926608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498875.5 → XP_006498938.1  myb-related protein B isoform X2

    Conserved Domains (3) summary
    PLN03091
    Location:81 → 219
    PLN03091; hypothetical protein; Provisional
    pfam09316
    Location:317 → 497
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:34 → 94
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  2. XM_006498876.5 → XP_006498939.1  myb-related protein B isoform X3

    See identical proteins and their annotated locations for XP_006498939.1

    Conserved Domains (2) summary
    PLN03091
    Location:2 → 57
    PLN03091; hypothetical protein; Provisional
    pfam09316
    Location:292 → 476
    Cmyb_C; C-myb, C-terminal

  3. XM_006498873.5 → XP_006498936.1  myb-related protein B isoform X1

    Conserved Domains (3) summary
    PLN03091
    Location:81 → 219
    PLN03091; hypothetical protein; Provisional
    pfam09316
    Location:454 → 638
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:34 → 94
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  4. XM_006498878.5 → XP_006498941.1  myb-related protein B isoform X4

    Conserved Domains (3) summary
    PLN03091
    Location:81 → 219
    PLN03091; hypothetical protein; Provisional
    pfam09316
    Location:317 → 458
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:34 → 94
    Myb_DNA-bind_6; Myb-like DNA-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48972.1 GenPept UniProtKB/Swiss-Prot:P48972

Gene LinkOut

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