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Myh2 myosin, heavy polypeptide 2, skeletal muscle, adult [ Mus musculus (house mouse) ]

Gene ID: 17882, updated on 21-Apr-2024

Summary

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Official Symbol
Myh2provided by MGI
Official Full Name
myosin, heavy polypeptide 2, skeletal muscle, adultprovided by MGI
Primary source
MGI:MGI:1339710
See related
Ensembl:ENSMUSG00000033196 AllianceGenome:MGI:1339710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MHC2A; Myh2a; Myhs-f; Myhsf1; Myhs-f1; MyHC-IIa
Summary
Acts upstream of or within actin-mediated cell contraction; plasma membrane repair; and response to activity. Located in several cellular components, including A band; Golgi apparatus; and actomyosin contractile ring. Is expressed in several structures, including alimentary system; forelimb bud mesenchyme; and skeletal musculature. Human ortholog(s) of this gene implicated in inclusion body myositis and proximal myopathy and ophthalmoplegia. Orthologous to human MYH2 (myosin heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 15.2), kidney adult (RPKM 2.7) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 40.59 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67061853..67088343)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67171027..67197517)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31285 Neighboring gene predicted gene, 53683 Neighboring gene STARR-seq mESC enhancer starr_29795 Neighboring gene STARR-seq mESC enhancer starr_29796 Neighboring gene myosin, heavy polypeptide 1, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Substrate curvature sensing through Myosin IIa upregulates early osteogenesis. Ozdemir T, et al. Integr Biol (Camb), 2013 Nov. PMID 24104522
  2. Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers. Jacobelli J, et al. PLoS One, 2013. PMID 24069389, Free PMC Article
  3. Comparing the effect of uniaxial cyclic mechanical stimulation and chemical factors on myogenin and Myh2 expression in mouse embryonic and bone marrow derived mesenchymal stem cells. Tannaz NA, et al. Mol Cell Biomech, 2014 Mar. PMID 25330622
  4. Analysis of the local organization and dynamics of cellular actin networks. Luo W, et al. J Cell Biol, 2013 Sep 30. PMID 24081490, Free PMC Article
  5. Myosin heavy chain 2A and α-actin expression in human and murine skeletal muscles at feeding; particularly amino acids. Iresjö BM, et al. J Transl Med, 2012 Nov 28. PMID 23190566, Free PMC Article

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly.
    Title: Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly.
  2. Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture.
    Title: Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture.
  3. myosin IIa is essential for B cell development, proliferation, and antibody responses.
    Title: Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation.
  4. nonmuscle myosin 2A replacement with myosin 2C1 permits gastrulation but not placenta vascular development in mice
    Title: Replacing nonmuscle myosin 2A with myosin 2C1 permits gastrulation but not placenta vascular development in mice.
  5. Inhibition of myosin IIA decreases annexin 1 nuclear translocation in oxygen-glucose deprivation.
    Title: Following OGD/R, annexin 1 nuclear translocation and subsequent induction of apoptosis in neurons are assisted by myosin IIA in a TRPM7 kinase-dependent manner.
  6. Myh2 expression was significantly higher in ESCs-mechanical group than that in the same group of MSCs.
    Title: Comparing the effect of uniaxial cyclic mechanical stimulation and chemical factors on myogenin and Myh2 expression in mouse embryonic and bone marrow derived mesenchymal stem cells.
  7. Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers.
    Title: Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers.
  8. Myosin IIa has a role in upregulating early osteogenesis
    Title: Substrate curvature sensing through Myosin IIa upregulates early osteogenesis.
  9. Myosin heavy chain 2A transcripts decreased significantly in skeletal muscle tissue from overnight parenterally fed patients but did not change significantly in orally refed mice
    Title: Myosin heavy chain 2A and α-actin expression in human and murine skeletal muscles at feeding; particularly amino acids.
  10. Increase of CYP1A1-mRNA was due to nonmuscle myosin II inhibition.
    Title: Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin-mediated cell contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within plasma membrane repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of muscle myosin complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myosin-2
Names
myosin heavy chain 2A
skeletal muscle myosin heavy chain II-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039545.2 → NP_001034634.2  myosin-2

    See identical proteins and their annotated locations for NP_001034634.2

    Status: VALIDATED

    Source sequence(s)
    AL596129
    Consensus CDS
    CCDS24854.2
    UniProtKB/TrEMBL
    B2RWX0, G3UW82
    Related
    ENSMUSP00000129544.2, ENSMUST00000170159.8
    Conserved Domains (7) summary
    cl22853
    Location:100 → 773
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:88 → 773
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:853 → 1930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    cl00459
    Location:1302 → 1414
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:1673 → 1770
    DUF342; Protein of unknown function (DUF342)
    cl23720
    Location:968 → 1101
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    67061853..67088343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144961.1: Suppressed sequence

    Description
    NM_144961.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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