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Mylpf myosin light chain, phosphorylatable, fast skeletal muscle [ Mus musculus (house mouse) ]

Gene ID: 17907, updated on 25-Jan-2022

Summary

Official Symbol
Mylpfprovided by MGI
Official Full Name
myosin light chain, phosphorylatable, fast skeletal muscleprovided by MGI
Primary source
MGI:MGI:97273
See related
Ensembl:ENSMUSG00000030672 AllianceGenome:MGI:97273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlc2; MLC-2; 2410014J02Rik
Summary
A structural constituent of muscle. Involved in skeletal muscle tissue development. Predicted to be part of myosin complex. Is expressed in several structures, including diaphragm; embryo mesenchyme; eye; limb; and musculature. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C. Orthologous to human MYLPF (myosin light chain, phosphorylatable, fast skeletal muscle). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in mammary gland adult (RPKM 230.4), limb E14.5 (RPKM 172.5) and 5 other tissues See more
Orthologs
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Genomic context

See Mylpf in Genome Data Viewer
Location:
7; 7 F3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126808071..126813459)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127208848..127214288)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (134355122..134357801)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene TBC1 domain family, member 10b Neighboring gene septin 1 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene zinc finger protein 771

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin regulatory light chain 2, skeletal muscle isoform
Names
MLC2F
fast skeletal myosin light chain 2
myosin light chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347655.1NP_001334584.1  myosin regulatory light chain 2, skeletal muscle isoform isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC122537
    Consensus CDS
    CCDS85420.1
    UniProtKB/TrEMBL
    A0A0U1RP93
    Related
    ENSMUSP00000145886.2, ENSMUST00000206772.2
    Conserved Domains (1) summary
    COG5126
    Location:1134
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_016754.5NP_058034.1  myosin regulatory light chain 2, skeletal muscle isoform isoform 1

    See identical proteins and their annotated locations for NP_058034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122537
    Consensus CDS
    CCDS40140.1
    UniProtKB/Swiss-Prot
    P97457
    UniProtKB/TrEMBL
    Q545G1
    Related
    ENSMUSP00000032910.7, ENSMUST00000032910.13
    Conserved Domains (1) summary
    COG5126
    Location:15154
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126808071..126813459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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