Myo9b myosin IXb [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo9bprovided by MGI
Official Full Name: myosin IXbprovided by MGI
Primary source: MGI:MGI:106624
See related: Ensembl:ENSMUSG00000004677 AllianceGenome:MGI:106624
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables GTPase activator activity and microfilament motor activity. Acts upstream of or within several processes, including Rho protein signal transduction; lamellipodium morphogenesis; and leukocyte chemotaxis. Located in filopodium tip; lamellipodium; and ruffle. Is expressed in brain; cerebellum; heart; inner ear; and skeletal muscle. Human ortholog(s) of this gene implicated in celiac disease. Orthologous to human MYO9B (myosin IXB). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 15.8), spleen adult (RPKM 13.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71725220..71813357)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71272576..71360713)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.
Title: Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.
Mutations in MYO9B are associated with Charcot-Marie-Tooth disease type 2 neuropathies and isolated optic atrophy.
Title: Mutations in MYO9B are associated with Charcot-Marie-Tooth disease type 2 neuropathies and isolated optic atrophy.
The RhoGAP-myosin Myo9b regulates ocular lens pit morphogenesis.
Title: The RhoGAP-myosin Myo9b regulates ocular lens pit morphogenesis.
TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response.
Title: TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating T(H)1/T(H)17 Cell Response.
Myo9b is critical for the CD8(+) T cell adaptation from lymphoid to nonlymphoid tissue surveillance and the establishment of protective tissue-resident T cell populations.
Title: The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8(+) T cells.
Myo9b regulates a subset of RhoA-activated processes necessary for IGF-1 responsiveness in osteogenic cells.
Title: The RhoGAP Myo9b Promotes Bone Growth by Mediating Osteoblastic Responsiveness to IGF-1.
This study shows that Myo9b in hematopoietic cells impacts on the induction and progression of EAE. Specifically, Myo9b regulates the onset of EAE symptoms, which correlates with immune cell proliferation and infiltration into the CNS.
Title: The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery.
we have identified Myo9b as a key regulator of spatiotemporal Rho activity in DCs with cofilin as a target protein of major importance for the regulation of DC migration and T cell stimulatory capacity.
Title: Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb.
Data identify the "motorized Rho inhibitor" Myo9b as a key molecular component required for spatially coordinated cell shape changes and motility.
Title: Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.
Myo9b functions as a motorized molecule in regions of actin polymerization and Myo9b head sequences are important for in vivo motor properties.
Title: The Myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:259375 (e-PCR)
- UniSTS:259375

Myo9b (e-PCR), detects polymorphism
- UniSTS:259375

Myo9b (e-PCR), detects polymorphism
- UniSTS:259376

Myo9b (e-PCR), detects polymorphism
- UniSTS:259377

AF143683 (e-PCR)
- UniSTS:179762

UniSTS:259378 (e-PCR)
- UniSTS:259378

Myo9b (e-PCR), detects polymorphism
- UniSTS:259378

Myo9b (e-PCR), detects polymorphism
- UniSTS:259379

AI237607 (e-PCR)
- UniSTS:250688

D8Mit233 (e-PCR), detects polymorphism
- UniSTS:131443

AU015531 (e-PCR)
- UniSTS:167588

D8Mit31 (e-PCR), detects polymorphism
- UniSTS:131524

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables Roundabout binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Roundabout signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin-myosin filament sliding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in filopodium tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-IXb

Names: unconventional myosin-9b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142322.2 → NP_001135794.1 unconventional myosin-IXb isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC157609

Consensus CDS

CCDS52580.1

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

UniProtKB/TrEMBL

E9PZW8

Related

ENSMUSP00000129220.2, ENSMUST00000170242.8

Conserved Domains (6) summary

cd01779
Location:7 → 112

Myosin_IXb_RA; ubitquitin-like domain of Myosin_IXb_RA

smart00015
Location:1000 → 1022

IQ; Calmodulin-binding motif

smart00242
Location:141 → 950

MYSc; Myosin. Large ATPases

cd00029
Location:1605 → 1653

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1670 → 1855

RhoGAP_myosin_IXB; RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a ...

cd01385
Location:160 → 941

MYSc_Myo9; class IX myosin, motor domain
NM_001142323.2 → NP_001135795.1 unconventional myosin-IXb isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC157609

Consensus CDS

CCDS52581.1

UniProtKB/TrEMBL

B9EHV1, E9PWZ6

Related

ENSMUSP00000131635.2, ENSMUST00000168839.9

Conserved Domains (6) summary

cd01779
Location:7 → 112

Myosin_IXb_RA; ubitquitin-like domain of Myosin_IXb_RA

smart00015
Location:1000 → 1022

IQ; Calmodulin-binding motif

smart00242
Location:141 → 950

MYSc; Myosin. Large ATPases

cd00029
Location:1605 → 1653

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1670 → 1855

RhoGAP_myosin_IXB; RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a ...

cd01385
Location:160 → 941

MYSc_Myo9; class IX myosin, motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71725220..71813357

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509566.2 → XP_006509629.1 unconventional myosin-IXb isoform X1

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2029 → 2123

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1036 → 1058

IQ; Calmodulin-binding motif

cd00029
Location:1641 → 1689

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1706 → 1891

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 977

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1207 → 1495

DUF4045; Domain of unknown function (DUF4045)
XM_006509579.3 → XP_006509642.1 unconventional myosin-IXb isoform X17

UniProtKB/TrEMBL

A0A1D5RLW4

Conserved Domains (6) summary

smart00015
Location:1036 → 1058

IQ; Calmodulin-binding motif

cd00029
Location:1641 → 1689

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1706 → 1891

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 977

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1207 → 1495

DUF4045; Domain of unknown function (DUF4045)
XM_006509572.2 → XP_006509635.1 unconventional myosin-IXb isoform X9

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2013 → 2107

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1036 → 1058

IQ; Calmodulin-binding motif

cd00029
Location:1641 → 1689

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1706 → 1891

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 977

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1207 → 1495

DUF4045; Domain of unknown function (DUF4045)
XM_006509567.2 → XP_006509630.1 unconventional myosin-IXb isoform X2

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2028 → 2122

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1036 → 1058

IQ; Calmodulin-binding motif

cd00029
Location:1640 → 1688

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1705 → 1890

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 977

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1207 → 1495

DUF4045; Domain of unknown function (DUF4045)
XM_006509569.2 → XP_006509632.1 unconventional myosin-IXb isoform X4

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2027 → 2121

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1036 → 1058

IQ; Calmodulin-binding motif

cd00029
Location:1639 → 1687

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1704 → 1889

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 977

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1207 → 1493

DUF4045; Domain of unknown function (DUF4045)
XM_017312599.2 → XP_017168088.1 unconventional myosin-IXb isoform X10

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2011 → 2105

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1036 → 1058

IQ; Calmodulin-binding motif

cd00029
Location:1639 → 1687

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1704 → 1889

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 977

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1207 → 1493

DUF4045; Domain of unknown function (DUF4045)
XM_017312598.2 → XP_017168087.1 unconventional myosin-IXb isoform X5

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2026 → 2120

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1036 → 1058

IQ; Calmodulin-binding motif

cd00029
Location:1638 → 1686

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1703 → 1888

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 977

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1207 → 1493

DUF4045; Domain of unknown function (DUF4045)
XM_017312600.2 → XP_017168089.1 unconventional myosin-IXb isoform X11

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2010 → 2104

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1036 → 1058

IQ; Calmodulin-binding motif

cd00029
Location:1638 → 1686

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1703 → 1888

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 977

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1207 → 1493

DUF4045; Domain of unknown function (DUF4045)
XM_006509571.2 → XP_006509634.1 unconventional myosin-IXb isoform X6

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2024 → 2118

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1031 → 1053

IQ; Calmodulin-binding motif

cd00029
Location:1636 → 1684

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1701 → 1886

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 972

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1202 → 1490

DUF4045; Domain of unknown function (DUF4045)
XM_036153785.1 → XP_036009678.1 unconventional myosin-IXb isoform X8

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (6) summary

PHA02682
Location:2022 → 2116

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1031 → 1053

IQ; Calmodulin-binding motif

cd04407
Location:1699 → 1884

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 972

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

cd20884
Location:1629 → 1686

C1_Myosin-IXb; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXb and similar proteins
XM_017312604.2 → XP_017168093.1 unconventional myosin-IXb isoform X22

UniProtKB/TrEMBL

A0A1D5RLW4

Related

ENSMUSP00000159515.1, ENSMUST00000240722.1

Conserved Domains (6) summary

smart00015
Location:1031 → 1053

IQ; Calmodulin-binding motif

cd00029
Location:1633 → 1681

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1698 → 1883

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 972

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1202 → 1488

DUF4045; Domain of unknown function (DUF4045)
XM_006509577.2 → XP_006509640.1 unconventional myosin-IXb isoform X15

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:1986 → 2080

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:993 → 1015

IQ; Calmodulin-binding motif

cd00029
Location:1598 → 1646

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1663 → 1848

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 934

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1164 → 1452

DUF4045; Domain of unknown function (DUF4045)
XM_006509575.2 → XP_006509638.1 unconventional myosin-IXb isoform X12

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:1999 → 2093

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1006 → 1028

IQ; Calmodulin-binding motif

cd00029
Location:1611 → 1659

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1676 → 1861

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 947

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1177 → 1465

DUF4045; Domain of unknown function (DUF4045)
XM_006509576.2 → XP_006509639.1 unconventional myosin-IXb isoform X13

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:1994 → 2088

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1001 → 1023

IQ; Calmodulin-binding motif

cd00029
Location:1606 → 1654

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1671 → 1856

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 942

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1172 → 1460

DUF4045; Domain of unknown function (DUF4045)
XM_030243333.1 → XP_030099193.1 unconventional myosin-IXb isoform X14

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:1992 → 2086

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1001 → 1023

IQ; Calmodulin-binding motif

cd00029
Location:1604 → 1652

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1669 → 1854

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 942

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1172 → 1458

DUF4045; Domain of unknown function (DUF4045)
XM_017312606.2 → XP_017168095.1 unconventional myosin-IXb isoform X24

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:1976 → 2070

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1001 → 1023

IQ; Calmodulin-binding motif

cd00029
Location:1604 → 1652

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1669 → 1854

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 942

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1172 → 1458

DUF4045; Domain of unknown function (DUF4045)
XM_036153787.1 → XP_036009680.1 unconventional myosin-IXb isoform X23

UniProtKB/TrEMBL

A0A1D5RLW4

Related

ENSMUSP00000148528.3, ENSMUST00000212412.3

Conserved Domains (5) summary

smart00015
Location:1001 → 1023

IQ; Calmodulin-binding motif

cd04407
Location:1668 → 1853

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 942

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

cd20884
Location:1598 → 1655

C1_Myosin-IXb; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXb and similar proteins
XM_006509568.2 → XP_006509631.1 unconventional myosin-IXb isoform X3

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2028 → 2122

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1035 → 1057

IQ; Calmodulin-binding motif

cd00029
Location:1640 → 1688

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1705 → 1890

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 976

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1206 → 1494

DUF4045; Domain of unknown function (DUF4045)
XM_030243331.1 → XP_030099191.1 unconventional myosin-IXb isoform X7

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:2023 → 2117

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1030 → 1052

IQ; Calmodulin-binding motif

cd00029
Location:1635 → 1683

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1700 → 1885

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 971

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1201 → 1489

DUF4045; Domain of unknown function (DUF4045)
XM_006509578.2 → XP_006509641.1 unconventional myosin-IXb isoform X16

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:1977 → 2071

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1000 → 1022

IQ; Calmodulin-binding motif

cd00029
Location:1605 → 1653

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1670 → 1855

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 941

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1171 → 1459

DUF4045; Domain of unknown function (DUF4045)
XM_017312607.2 → XP_017168096.1 unconventional myosin-IXb isoform X25

UniProtKB/Swiss-Prot

Q9QY06, Q9QY07, Q9QY08, Q9QY09

Conserved Domains (7) summary

PHA02682
Location:1974 → 2068

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:1000 → 1022

IQ; Calmodulin-binding motif

cd00029
Location:1602 → 1650

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04407
Location:1667 → 1852

RhoGAP_myosin_IXB; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 941

MYSc_Myo9; class IX myosin, motor domain

cd17217
Location:16 → 112

RA_Myosin-IXb; Ras-associating (RA) domain found in Myosin-IXb

pfam13254
Location:1171 → 1457

DUF4045; Domain of unknown function (DUF4045)
XM_006509580.1 → XP_006509643.1 unconventional myosin-IXb isoform X18

Conserved Domains (6) summary

PHA02682
Location:1450 → 1544

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:457 → 479

IQ; Calmodulin-binding motif

cd00029
Location:1062 → 1110

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl22853
Location:20 → 398

Motor_domain; Myosin and Kinesin motor domain

pfam13254
Location:628 → 916

DUF4045; Domain of unknown function (DUF4045)

cl02570
Location:1127 → 1312

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_006509585.1 → XP_006509648.1 unconventional myosin-IXb isoform X21

See identical proteins and their annotated locations for XP_006509648.1

Conserved Domains (6) summary

PHA02682
Location:1189 → 1283

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:196 → 218

IQ; Calmodulin-binding motif

cd00029
Location:801 → 849

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl22853
Location:1 → 137

Motor_domain; Myosin and Kinesin motor domain

pfam13254
Location:367 → 655

DUF4045; Domain of unknown function (DUF4045)

cl02570
Location:866 → 1051

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_006509581.1 → XP_006509644.1 unconventional myosin-IXb isoform X19

See identical proteins and their annotated locations for XP_006509644.1

Conserved Domains (5) summary

PHA02682
Location:1226 → 1320

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:233 → 255

IQ; Calmodulin-binding motif

cd00029
Location:838 → 886

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl22853
Location:37 → 174

Motor_domain; Myosin and Kinesin motor domain

cl02570
Location:903 → 1088

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_036153786.1 → XP_036009679.1 unconventional myosin-IXb isoform X20

Conserved Domains (5) summary

PHA02682
Location:1223 → 1317

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:233 → 255

IQ; Calmodulin-binding motif

cd20884
Location:830 → 887

C1_Myosin-IXb; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXb and similar proteins

cl02570
Location:900 → 1085

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl22853
Location:37 → 174

Motor_domain; Myosin and Kinesin motor domain
XM_006509582.1 → XP_006509645.1 unconventional myosin-IXb isoform X19

See identical proteins and their annotated locations for XP_006509645.1

Conserved Domains (5) summary

PHA02682
Location:1226 → 1320

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:233 → 255

IQ; Calmodulin-binding motif

cd00029
Location:838 → 886

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl22853
Location:37 → 174

Motor_domain; Myosin and Kinesin motor domain

cl02570
Location:903 → 1088

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_006509584.4 → XP_006509647.1 unconventional myosin-IXb isoform X19

See identical proteins and their annotated locations for XP_006509647.1

Conserved Domains (5) summary

PHA02682
Location:1226 → 1320

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:233 → 255

IQ; Calmodulin-binding motif

cd00029
Location:838 → 886

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl22853
Location:37 → 174

Motor_domain; Myosin and Kinesin motor domain

cl02570
Location:903 → 1088

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_006509586.4 → XP_006509649.1 unconventional myosin-IXb isoform X21

See identical proteins and their annotated locations for XP_006509649.1

Conserved Domains (6) summary

PHA02682
Location:1189 → 1283

PHA02682; ORF080 virion core protein; Provisional

smart00015
Location:196 → 218

IQ; Calmodulin-binding motif

cd00029
Location:801 → 849

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl22853
Location:1 → 137

Motor_domain; Myosin and Kinesin motor domain

pfam13254
Location:367 → 655

DUF4045; Domain of unknown function (DUF4045)

cl02570
Location:866 → 1051

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...