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Naip6 NLR family, apoptosis inhibitory protein 6 [ Mus musculus (house mouse) ]

Gene ID: 17952, updated on 11-Apr-2024

Summary

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Official Symbol
Naip6provided by MGI
Official Full Name
NLR family, apoptosis inhibitory protein 6provided by MGI
Primary source
MGI:MGI:1298222
See related
Ensembl:ENSMUSG00000078942 AllianceGenome:MGI:1298222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Birc1f; Naip-rs4; Naip-rs4A
Summary
Predicted to enable ATP binding activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in inflammatory response; pyroptosis; and response to bacterium. Acts upstream of or within cellular response to estrogen stimulus. Part of IPAF inflammasome complex. Is expressed in genitourinary system and spinal cord. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 23.3), small intestine adult (RPKM 13.1) and 7 other tissues See more
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Genomic context

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Location:
13 D1; 13 53.09 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100417629..100453124, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100281121..100316616, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene NLR family, apoptosis inhibitory protein 2 Neighboring gene NLR family, apoptosis inhibitory protein 1, related sequence 1 Neighboring gene STARR-seq mESC enhancer starr_35472 Neighboring gene STARR-seq mESC enhancer starr_35473 Neighboring gene NLR family, apoptosis inhibitory protein 5 Neighboring gene STARR-seq mESC enhancer starr_35474 Neighboring gene NLR family, apoptosis inhibitory protein 3, pseudogene 1 Neighboring gene NLR family, apoptosis inhibitory protein 3 Neighboring gene ubiquitin specific peptidase 38 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Wright EK, et al. Curr Biol, 2003 Jan 8. PMID 12526741
  2. The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells. Götz R, et al. Hum Mol Genet, 2000 Oct 12. PMID 11030753
  3. The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts. Huang S, et al. Mamm Genome, 1999 Oct. PMID 10501978
  4. NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. Rauch I, et al. J Exp Med, 2016 May 2. PMID 27045008, Free PMC Article
  5. The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila. Diez E, et al. J Immunol, 2000 Feb 1. PMID 10640764

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyroptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_negative_effect regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of IPAF inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of IPAF inflammasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
baculoviral IAP repeat-containing protein 1f
Names
neuronal apoptosis inhibitory protein 6
neuronal apoptosis inhibitory protein, related sequence 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010871.2 → NP_035001.2  baculoviral IAP repeat-containing protein 1f

    See identical proteins and their annotated locations for NP_035001.2

    Status: VALIDATED

    Source sequence(s)
    AF135494
    Consensus CDS
    CCDS26728.1
    UniProtKB/Swiss-Prot
    P81704, Q8CH68, Q9JIB6
    UniProtKB/TrEMBL
    Q8CH64
    Related
    ENSMUSP00000041766.3, ENSMUST00000042220.3
    Conserved Domains (6) summary
    cd09293
    Location:1072 → 1271
    AMN1; Antagonist of mitotic exit network protein 1
    smart00238
    Location:277 → 346
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:61 → 129
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    sd00034
    Location:1132 → 1156
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00653
    Location:162 → 228
    BIR; Inhibitor of Apoptosis domain
    pfam05729
    Location:464 → 618
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100417629..100453124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIB6.2 GenPept UniProtKB/Swiss-Prot:Q9JIB6

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