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elpc-3 Elongator complex protein 3 [ Caenorhabditis elegans ]

Gene ID: 179669, updated on 23-Nov-2023

Summary

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Gene symbol
elpc-3
Gene description
Elongator complex protein 3
Primary source
WormBase:WBGene00014123
Locus tag
CELE_ZK863.3
See related
AllianceGenome:WB:WBGene00014123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphorylase kinase regulator activity. Involved in several processes, including gamete generation; olfactory learning; and tRNA wobble uridine modification. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including CAN; HSN; amphid neurons; pharynx; and vulva. Used to study Riley-Day syndrome. Orthologous to human ELP3 (elongator acetyltransferase complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (12179497..12181410, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene U6 snRNA-specific terminal uridylyltransferase Neighboring gene G protein-coupled receptor Neighboring gene UPAR/Ly6 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. Solinger JA, et al. PLoS Genet, 2010 Jan 22. PMID 20107598, Free PMC Article
  2. Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants. Chen C, et al. PLoS Genet, 2009 Jul. PMID 19593383, Free PMC Article
  3. Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. Pastore C, et al. J Biol Chem, 2012 Jan 13. PMID 22065580, Free PMC Article
  4. The protein kinase G orthologs, EGL-4 and PKG-2, mediate serotonin-induced paralysis of C. elegans. Olson A, et al. MicroPubl Biol, 2019 May 24. PMID 32550449, Free PMC Article
  5. Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans. Kim S, et al. Genetics, 2010 Aug. PMID 20479142, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elpc1 and elpc3 complex regulates neuronal alpha-tubulin acetylation.
    Title: The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorylase kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA uridine(34) acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryonic morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Elongator complex protein 3
NP_506055.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12179497..12181410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073654.5 → NP_506055.2  Elongator complex protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506055.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23651
    Conserved Domains (1) summary
    TIGR01211
    Location:17 → 542
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23651.2

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