Format

Send to:

Choose Destination

Ncf4 neutrophil cytosolic factor 4 [ Mus musculus (house mouse) ]

Gene ID: 17972, updated on 8-Jul-2021

Summary

Official Symbol
Ncf4provided by MGI
Official Full Name
neutrophil cytosolic factor 4provided by MGI
Primary source
MGI:MGI:109186
See related
Ensembl:ENSMUSG00000071715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p40p; p40phox; AI451400
Expression
Biased expression in spleen adult (RPKM 34.0), liver E18 (RPKM 15.5) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ncf4 in Genome Data Viewer
Location:
15 E1; 15 37.1 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78128364..78146782)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78244164..78262582)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (78075241..78093010)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 27 Neighboring gene parvalbumin Neighboring gene microRNA 7676-1 Neighboring gene colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) Neighboring gene colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Neighboring gene microRNA 7676-2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables superoxide-generating NADPH oxidase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in respiratory burst IEA
Inferred from Electronic Annotation
more info
 
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neutrophil cytosol factor 4
Names
NCF-4
neutrophil NADPH oxidase factor 4
p40-phox

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008677.2NP_032703.2  neutrophil cytosol factor 4

    See identical proteins and their annotated locations for NP_032703.2

    Status: VALIDATED

    Source sequence(s)
    AA016555, AK150510, BB840090
    Consensus CDS
    CCDS27610.1
    UniProtKB/Swiss-Prot
    P97369
    Related
    ENSMUSP00000094084.6, ENSMUST00000096357.12
    Conserved Domains (3) summary
    cd06399
    Location:238329
    PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
    cd06882
    Location:19141
    PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
    cd11869
    Location:174227
    SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78128364..78146782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520565.2XP_006520628.1  neutrophil cytosol factor 4 isoform X1

    See identical proteins and their annotated locations for XP_006520628.1

    UniProtKB/Swiss-Prot
    P97369
    Conserved Domains (3) summary
    cd06399
    Location:238329
    PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
    cd06882
    Location:19141
    PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
    cd11869
    Location:174227
    SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase
  2. XM_036159223.1XP_036015116.1  neutrophil cytosol factor 4 isoform X4

    Conserved Domains (2) summary
    cd06882
    Location:19141
    PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
    cl17036
    Location:174209
    SH3; Src Homology 3 domain superfamily
  3. XM_036159221.1XP_036015114.1  neutrophil cytosol factor 4 isoform X2

    Related
    ENSMUSP00000121191.3, ENSMUST00000133618.3
    Conserved Domains (3) summary
    cd06882
    Location:19141
    PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
    cd11869
    Location:174227
    SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase
    cl02720
    Location:238275
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
  4. XM_006520564.2XP_006520627.1  neutrophil cytosol factor 4 isoform X1

    See identical proteins and their annotated locations for XP_006520627.1

    UniProtKB/Swiss-Prot
    P97369
    Conserved Domains (3) summary
    cd06399
    Location:238329
    PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
    cd06882
    Location:19141
    PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
    cd11869
    Location:174227
    SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase
  5. XM_036159222.1XP_036015115.1  neutrophil cytosol factor 4 isoform X3

    Conserved Domains (3) summary
    cd06399
    Location:144235
    PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
    cd11869
    Location:80133
    SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase
    cl02563
    Location:147
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
Support Center