hmit-1.1 Proton myo-inositol cotransporter hmit-1.1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: hmit-1.1
Gene description: Proton myo-inositol cotransporter hmit-1.1
Primary source: WormBase:WBGene00013073
Locus tag: CELE_Y51A2D.4
See related: AllianceGenome:WB:WBGene00013073
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable myo-inositol:proton symporter activity. Predicted to be involved in myo-inositol transport and transmembrane transport. Located in apical plasma membrane. Is expressed in intestine. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See hmit-1.1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (18516789..18523875)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that the C. elegans HMIT family has a crucial role in the osmoprotective response.
Title: H+/myo-inositol transporter genes, hmit-1.1 and hmit-1.2, have roles in the osmoprotective response in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y51A2D.4 (e-PCR)
- UniSTS:313331

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables myo-inositol:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in myo-inositol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Proton myo-inositol cotransporter hmit-1.1

NP_507623.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

18516789..18523875

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075222.5 → NP_507623.1 Proton myo-inositol cotransporter hmit-1.1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507623.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XXR3

Conserved Domains (1) summary

cd17360
Location:31 → 554

MFS_HMIT_like; H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily