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ncx-1 Calx-beta domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180318, updated on 11-Apr-2024

Summary

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Gene symbol
ncx-1
Gene description
Calx-beta domain-containing protein
Primary source
WormBase:WBGene00003566
Locus tag
CELE_Y113G7A.4
See related
AllianceGenome:WB:WBGene00003566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Predicted to be integral component of plasma membrane. Is expressed in AIYL and AIYR. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1); SLC8A2 (solute carrier family 8 member A2); and SLC8A3 (solute carrier family 8 member A3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
15
Sequence:
Chromosome: V; NC_003283.11 (20105633..20120673, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase Neighboring gene Protein transport protein SEC23 Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium:sodium antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Calx-beta domain-containing protein
NP_001041182.1
  • Confirmed by transcript evidence
NP_001041183.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20105633..20120673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047717.7 → NP_001041182.1  Calx-beta domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041182.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF08
    Conserved Domains (5) summary
    smart00237
    Location:511 → 600
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:44 → 880
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:706 → 871
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:388 → 478
    Calx-beta; Calx-beta domain
    pfam16494
    Location:283 → 370
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  2. NM_001047718.6 → NP_001041183.1  Calx-beta domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041183.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1RPT9
    Conserved Domains (4) summary
    smart00237
    Location:511 → 600
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    pfam01699
    Location:706 → 795
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:388 → 478
    Calx-beta; Calx-beta domain
    pfam16494
    Location:283 → 370
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
Nucleotide Protein
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