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DPYSL3 dihydropyrimidinase like 3 [ Homo sapiens (human) ]

Gene ID: 1809, updated on 5-Sep-2021

Summary

Official Symbol
DPYSL3provided by HGNC
Official Full Name
dihydropyrimidinase like 3provided by HGNC
Primary source
HGNC:HGNC:3015
See related
Ensembl:ENSG00000113657 MIM:601168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRP3; ULIP; CRMP4; DRP-3; LCRMP; CRMP-4; ULIP-1
Expression
Broad expression in brain (RPKM 51.8), prostate (RPKM 49.3) and 22 other tissues See more
Orthologs
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Genomic context

See DPYSL3 in Genome Data Viewer
Location:
5q32
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (147390808..147510068, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (146770371..146889631, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene uncharacterized LOC105378214 Neighboring gene PPP2R2B intronic transcript 1 Neighboring gene STK32A antisense RNA 1 Neighboring gene serine/threonine kinase 32A Neighboring gene JAKMIP2 antisense RNA 1 Neighboring gene uncharacterized LOC101927012 Neighboring gene janus kinase and microtubule interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chondroitin sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT enables dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables filamin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin crosslink formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to axon injury ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with exocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of filamentous actin ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dihydropyrimidinase-related protein 3
Names
collapsin response mediator protein 4 long
testicular secretory protein Li 7
unc-33-like phosphoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197294.2NP_001184223.1  dihydropyrimidinase-related protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001184223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011373, BC077077, CA424493, D78014
    Consensus CDS
    CCDS56387.1
    UniProtKB/Swiss-Prot
    Q14195
    UniProtKB/TrEMBL
    A0A140VK07, Q6DEN2
    Related
    ENSP00000343690.5, ENST00000343218.10
    Conserved Domains (2) summary
    TIGR02033
    Location:131585
    D-hydantoinase
    cl14632
    Location:574679
    VOC; vicinal oxygen chelate (VOC) family
  2. NM_001387.3NP_001378.1  dihydropyrimidinase-related protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform (1).
    Source sequence(s)
    AI570709, BC039006, CA424493, D78014
    Consensus CDS
    CCDS43381.1
    UniProtKB/Swiss-Prot
    Q14195
    UniProtKB/TrEMBL
    Q8IXW6
    Related
    ENSP00000381526.3, ENST00000398514.7
    Conserved Domains (1) summary
    TIGR02033
    Location:17471
    D-hydantoinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    147390808..147510068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537574.2XP_011535876.1  dihydropyrimidinase-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011535876.1

    Conserved Domains (2) summary
    TIGR02033
    Location:13467
    D-hydantoinase
    cl14632
    Location:456561
    VOC; vicinal oxygen chelate (VOC) family
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