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Nkx2-5 NK2 homeobox 5 [ Mus musculus (house mouse) ]

Gene ID: 18091, updated on 30-Nov-2021

Summary

Official Symbol
Nkx2-5provided by MGI
Official Full Name
NK2 homeobox 5provided by MGI
Primary source
MGI:MGI:97350
See related
Ensembl:ENSMUSG00000015579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csx; Nkx2.5; tinman; Nkx-2.5
Expression
Biased expression in heart adult (RPKM 27.8), spleen adult (RPKM 10.5) and 1 other tissue See more
Orthologs
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Genomic context

See Nkx2-5 in Genome Data Viewer
Location:
17 A3.3; 17 13.6 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27057638..27063962, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26838664..26844988, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (26975610..26978510, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CREB3 regulatory factor Neighboring gene BCL2/adenovirus E1B interacting protein 1 Neighboring gene VISTA enhancer mm1645 Neighboring gene predicted gene, 53221 Neighboring gene predicted gene, 17382 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Purkinje myocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adult heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adult heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial cardiac muscle cell development TAS
Traceable Author Statement
more info
PubMed 
involved_in atrial cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within atrioventricular node cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within atrioventricular node cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bundle of His development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cardiac conduction system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cardiac conduction system development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac ventricle formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cardiac ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within circulatory system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic heart tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic heart tube left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoderm development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within heart contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pharyngeal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cardioblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription initiation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription via serum response element binding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proepicardium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pulmonary myocardium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in right ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sarcomere organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in septum secundum development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in spleen development ISO
Inferred from Sequence Orthology
more info
 
involved_in spleen development TAS
Traceable Author Statement
more info
PubMed 
involved_in thyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in tongue development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular cardiac muscle cell development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within ventricular cardiac myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
homeobox protein Nkx-2.5
Names
Drosophila NK2 transcription factor related, locus 5
NK2 transcription factor related, locus 5
cardiac-specific homeobox
homeobox protein CSX
homeobox protein NK-2 homolog E

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008700.2NP_032726.1  homeobox protein Nkx-2.5

    See identical proteins and their annotated locations for NP_032726.1

    Status: VALIDATED

    Source sequence(s)
    AC144621, AK142146
    Consensus CDS
    CCDS28556.1
    UniProtKB/Swiss-Prot
    P42582
    UniProtKB/TrEMBL
    Q3UQU2
    Related
    ENSMUSP00000015723.5, ENSMUST00000015723.5
    Conserved Domains (1) summary
    pfam00046
    Location:144194
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27057638..27063962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523797.4XP_006523860.1  homeobox protein Nkx-2.5 isoform X1

    See identical proteins and their annotated locations for XP_006523860.1

    UniProtKB/Swiss-Prot
    P42582
    UniProtKB/TrEMBL
    Q3UQU2
    Related
    ENSMUSP00000157537.2, ENSMUST00000235454.2
    Conserved Domains (1) summary
    pfam00046
    Location:144194
    Homeobox; Homeobox domain
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