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nuc-1 Deoxyribonuclease-2 [ Caenorhabditis elegans ]

Gene ID: 181174, updated on 23-Nov-2023

Summary

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Gene symbol
nuc-1
Gene description
Deoxyribonuclease-2
Primary source
WormBase:WBGene00003828
Locus tag
CELE_C07B5.5
See related
AllianceGenome:WB:WBGene00003828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Located in lysosome. Orthologous to several human genes including DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nuc-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (9539905..9542329)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Nucleolar protein 16;Translation initiation factor IF-2 Neighboring gene tRNA-Val

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II. Lyon CJ, et al. Gene, 2000 Jul 11. PMID 10903446
  2. Structure, evolution and properties of a novel repetitive DNA family in Caenorhabditis elegans. La Volpe A, et al. Nucleic Acids Res, 1988 Sep 12. PMID 3419918, Free PMC Article
  3. An endonuclease from Caenorhabditis elegans: partial purification and characterization. Hevelone J, et al. Biochem Genet, 1988 Aug. PMID 3228446
  4. Post-embryonic development in the ventral cord of Caenorhabditis elegans. Sulston JE. Philos Trans R Soc Lond B Biol Sci, 1976 Aug 10. PMID 8804
  5. The Caenorhabditis elegans RAD51 homolog is transcribed into two alternative mRNAs potentially encoding proteins of different sizes. Rinaldo C, et al. Mol Gen Genet, 1998 Nov. PMID 9862483

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuc-1 is principally responsible for degradation of apoptotic DNA during embryogenesis.
    Title: Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos.
  2. Nuc-1 plays a role in degrading apoptotic DNA in distinct sites of the gonad.
    Title: Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables deoxyribonuclease II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyribonuclease II activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyribonuclease II activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic DNA fragmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_positive_effect negative regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Deoxyribonuclease-2
NP_509604.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9539905..9542329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077203.9 → NP_509604.1  Deoxyribonuclease-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509604.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17778
    Conserved Domains (3) summary
    cd09120
    Location:21 → 191
    PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins
    cd09121
    Location:238 → 374
    PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins
    pfam03265
    Location:24 → 371
    DNase_II; Deoxyribonuclease II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17778.1

Gene LinkOut

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