Format

Send to:

Choose Destination

DRD1 dopamine receptor D1 [ Homo sapiens (human) ]

Gene ID: 1812, updated on 6-Sep-2021

Summary

Official Symbol
DRD1provided by HGNC
Official Full Name
dopamine receptor D1provided by HGNC
Primary source
HGNC:HGNC:3020
See related
Ensembl:ENSG00000184845 MIM:126449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DADR; DRD1A
Summary
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.4), placenta (RPKM 0.8) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DRD1 in Genome Data Viewer
Location:
5q35.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (175440036..175444182, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (174867039..174871185, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8865 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 6 Neighboring gene sideroflexin 1 Neighboring gene RN7SK pseudogene 148

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adult walking behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to catecholamine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to dopamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex GABAergic interneuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dopamine metabolic process IC
Inferred by Curator
more info
PubMed 
involved_in dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mating behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipase C-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in prepulse inhibition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of dopamine uptake involved in synaptic transmission IC
Inferred by Curator
more info
PubMed 
involved_in response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
involved_in transmission of nerve impulse ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
involved_in visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
D(1A) dopamine receptor
Names
dopamine D1 receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011802.1 RefSeqGene

    Range
    4979..9125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000794.5NP_000785.1  D(1A) dopamine receptor

    See identical proteins and their annotated locations for NP_000785.1

    Status: REVIEWED

    Source sequence(s)
    AC091393
    Consensus CDS
    CCDS4393.1
    UniProtKB/Swiss-Prot
    P21728
    Related
    ENSP00000377353.1, ENST00000393752.3
    Conserved Domains (1) summary
    cd15320
    Location:23341
    7tmA_D1A_dopamine_R; D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    175440036..175444182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center