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Nos1 nitric oxide synthase 1, neuronal [ Mus musculus (house mouse) ]

Gene ID: 18125, updated on 5-Jan-2022

Summary

Official Symbol
Nos1provided by MGI
Official Full Name
nitric oxide synthase 1, neuronalprovided by MGI
Primary source
MGI:MGI:97360
See related
Ensembl:ENSMUSG00000029361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NO; NOS; bNOS; nNOS; N-NOS; NOS-I; Nos-1; NC-NOS; 2310005C01Rik
Summary
Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; and regulation of metal ion transport. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in cerebellum adult (RPKM 7.6), frontal lobe adult (RPKM 4.0) and 12 other tissues See more
Orthologs
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Genomic context

See Nos1 in Genome Data Viewer
Location:
5 F; 5 57.29 cM
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118004904..118096905)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117866839..117958840)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (118317128..118403822)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52829 Neighboring gene kinase suppressor of ras 2 Neighboring gene predicted gene, 42013 Neighboring gene Nos1 exon 2 regulatory region Neighboring gene predicted gene, 30360 Neighboring gene predicted gene, 26995 Neighboring gene F-box protein 21 Neighboring gene tescalcin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables FMN binding ISO
Inferred from Sequence Orthology
more info
 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
 
enables cadmium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nitric-oxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in arginine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arginine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organismal response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hepatic stellate cell contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of iron ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of serotonin uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-cysteine S-nitrosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-cysteine S-nitrosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde trans-synaptic signaling by nitric oxide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde trans-synaptic signaling by nitric oxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic signaling by nitric oxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic signaling by nitric oxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within xenobiotic catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nitric oxide synthase, brain
Names
NOS type I
constitutive NOS
neuronal NOS
neuronal nitric oxide synthase
peptidyl-cysteine S-nitrosylase NOS1
NP_032738.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008712.3NP_032738.1  nitric oxide synthase, brain

    See identical proteins and their annotated locations for NP_032738.1

    Status: VALIDATED

    Source sequence(s)
    AC114617, AC114993
    Consensus CDS
    CCDS19606.1
    UniProtKB/Swiss-Prot
    Q9Z0J4
    Related
    ENSMUSP00000127432.2, ENSMUST00000171055.2
    Conserved Domains (5) summary
    cd06202
    Location:9961399
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    COG0369
    Location:7541394
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757930
    Flavodoxin_1; Flavodoxin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    118004904..118096905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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