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Pnoc prepronociceptin [ Mus musculus (house mouse) ]

Gene ID: 18155, updated on 6-Jul-2021

Summary

Official Symbol
Pnocprovided by MGI
Official Full Name
prepronociceptinprovided by MGI
Primary source
MGI:MGI:105308
See related
Ensembl:ENSMUSG00000045731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p; Np; N/O; N23; OFQ; N/OFQ; Npnc1; OFQ/N
Summary
This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
Expression
Biased expression in whole brain E14.5 (RPKM 9.2), CNS E14 (RPKM 8.2) and 10 other tissues See more
Orthologs
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Genomic context

See Pnoc in Genome Data Viewer
Location:
14; 14 D1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65638122..65663130, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65400673..65425564, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66019510..66044046, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene F-box protein 16 Neighboring gene predicted gene, 41178 Neighboring gene predicted gene, 48449 Neighboring gene zinc finger protein 395 Neighboring gene RIKEN cDNA 9530047P18 gene Neighboring gene elongator acetyltransferase complex subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables opioid peptide activity IEA
Inferred from Electronic Annotation
more info
 
enables opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
prepronociceptin
Names
neuropeptide nociceptin 1
orphanin FQ
proorphanin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205075.1NP_001192004.1  prepronociceptin isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001192004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon compared to variant 1. This results in a frameshift, and a longer isoform (2, also known as N27K) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC158983, AK045893
    Consensus CDS
    CCDS88690.1
    UniProtKB/Swiss-Prot
    Q64387
    UniProtKB/TrEMBL
    B7ZMX9, Q543U6
    Related
    ENSMUSP00000153589.2, ENSMUST00000224594.2
    Conserved Domains (1) summary
    pfam01160
    Location:2165
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  2. NM_010932.2NP_035062.1  prepronociceptin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_035062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1, also known as N23K).
    Source sequence(s)
    AC158983, AK045893
    Consensus CDS
    CCDS27213.1
    UniProtKB/Swiss-Prot
    Q64387
    UniProtKB/TrEMBL
    Q543U6
    Related
    ENSMUSP00000054210.6, ENSMUST00000059339.6
    Conserved Domains (1) summary
    pfam01160
    Location:2165
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    65638122..65663130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518684.4XP_006518747.1  prepronociceptin isoform X1

    See identical proteins and their annotated locations for XP_006518747.1

    UniProtKB/Swiss-Prot
    Q64387
    UniProtKB/TrEMBL
    B7ZMX9
    Conserved Domains (1) summary
    pfam01160
    Location:2165
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  2. XM_030247683.2XP_030103543.1  prepronociceptin isoform X2

    Conserved Domains (1) summary
    pfam01160
    Location:2165
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
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