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dyn-1 Dynamin [ Caenorhabditis elegans ]

Gene ID: 181644, updated on 11-Apr-2024

Summary

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Gene symbol
dyn-1
Gene description
Dynamin
Primary source
WormBase:WBGene00001130
Locus tag
CELE_C02C6.1
See related
AllianceGenome:WB:WBGene00001130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activity. Involved in several processes, including phagosome maturation involved in apoptotic cell clearance; positive regulation of necrotic cell death; and receptor-mediated endocytosis. Located in several cellular components, including cleavage furrow; periciliary membrane compartment; and pseudopodium. Is expressed in several structures, including hermaphrodite gonad; hypodermis; nervous system; pharynx; and rectal valve cell. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; developmental and epileptic encephalopathy 31; and lethal congenital contracture syndrome. Orthologous to human DNM1 (dynamin 1); DNM2 (dynamin 2); and DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (15568921..15573021)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Aspartyl/asparaginy/proline hydroxylase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis. Thompson HM, et al. Curr Biol, 2002 Dec 23. PMID 12498685, Free PMC Article
  2. Enhanced pentylenetetrazole sensitivity in a C. elegans mutant associated with DNM1 encephalopathy. Vaji MA, et al. MicroPubl Biol, 2020 Aug 20. PMID 32844156, Free PMC Article
  3. Targeted gene deletions in C. elegans using transposon excision. Frøkjaer-Jensen C, et al. Nat Methods, 2010 Jun. PMID 20418868, Free PMC Article
  4. Contribution of the GTPase domain to the subcellular localization of dynamin in the nematode Caenorhabditis elegans. Labrousse AM, et al. Mol Biol Cell, 1998 Nov. PMID 9802908, Free PMC Article
  5. A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans. Clark SG, et al. Proc Natl Acad Sci U S A, 1997 Sep 16. PMID 9294229, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dynamin is a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis
    Title: A multiscale study of the role of dynamin in the regulation of glucose uptake.
  2. RAB-5- and DYNAMIN-1-mediated endocytosis of EFF-1 fusogen controls cell-cell fusion.
    Title: RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion.
  3. PAR-3 and PAR-6 function in cytokinesis may be partially redundant and play a role in the maintenance of DYN-1 in the cleavage furrow.
    Title: Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.
  4. Results describe the oligomerization of dynamin-1 (DYN-1) in living C. elegans embryos and identified DYN-1 mutations that abolish DYN-1's oligomerization or GTPase activities.
    Title: Live-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells.
  5. The Caenorhabditis elegans dynamin ortholog, DYN-1, maintains anterior polarity cues.
    Title: Dynamin participates in the maintenance of anterior polarity in the Caenorhabditis elegans embryo.
  6. In Caenorhabditis elegans, dynamin localized to newly formed cleavage furrow membranes and accumulated at the midbody of dividing embryos in a manner similar to dynamin localization in mammalian cells
    Title: The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in necroptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in phagosome maturation involved in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periciliary membrane compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dynamin
NP_001024332.1
  • Confirmed by transcript evidence
NP_001359587.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15568921..15573021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373600.5 → NP_001359587.1  Dynamin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39055, Q93176, Q95QY9
    UniProtKB/TrEMBL
    Q9U9I9
    Conserved Domains (4) summary
    cd08771
    Location:31 → 296
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    cd01256
    Location:518 → 628
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:218 → 505
    Dynamin_M; Dynamin central region
    pfam02212
    Location:650 → 739
    GED; Dynamin GTPase effector domain

  2. NM_001029161.5 → NP_001024332.1  Dynamin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024332.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U9I9
    Conserved Domains (6) summary
    smart00302
    Location:648 → 739
    GED; Dynamin GTPase effector domain
    cd08771
    Location:31 → 296
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:80 → 567
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:518 → 628
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:520 → 622
    PH; PH domain
    pfam01031
    Location:219 → 505
    Dynamin_M; Dynamin central region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39055.3

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