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Ntf3 neurotrophin 3 [ Mus musculus (house mouse) ]

Gene ID: 18205, updated on 8-Jul-2021

Summary

Official Symbol
Ntf3provided by MGI
Official Full Name
neurotrophin 3provided by MGI
Primary source
MGI:MGI:97380
See related
Ensembl:ENSMUSG00000049107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NT; NT-; Nt3; HDNF; Ntf-; NGF-2; Ntf-3; AI316846; AI835689
Summary
This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]
Expression
Broad expression in bladder adult (RPKM 4.6), limb E14.5 (RPKM 4.0) and 21 other tissues See more
Orthologs
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Genomic context

See Ntf3 in Genome Data Viewer
Location:
6 F3; 6 60.45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126078375..126143734, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126101412..126166772, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (126051430..126116762, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene anoctamin 2 Neighboring gene predicted gene, 33202 Neighboring gene predicted gene, 24947 Neighboring gene predicted gene 10415 Neighboring gene predicted gene, 33276 Neighboring gene 60S ribosomal protein L32 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables nerve growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurotrophin p75 receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables neurotrophin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within generation of neurons IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glial cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in induction of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mechanoreceptor differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in nerve development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neurotrophin-3
Names
nerve growth factor 2
neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164034.1NP_001157506.1  neurotrophin-3 isoform a

    See identical proteins and their annotated locations for NP_001157506.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AA198264, AK132586, BC065785
    Consensus CDS
    CCDS51914.1
    UniProtKB/Swiss-Prot
    P20181
    UniProtKB/TrEMBL
    Q3V1A4
    Related
    ENSMUSP00000107863.3, ENSMUST00000112244.8
    Conserved Domains (1) summary
    pfam00243
    Location:158267
    NGF; Nerve growth factor family
  2. NM_001164035.1NP_001157507.1  neurotrophin-3 isoform a

    See identical proteins and their annotated locations for NP_001157507.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK132586, BC065785
    Consensus CDS
    CCDS51914.1
    UniProtKB/Swiss-Prot
    P20181
    UniProtKB/TrEMBL
    Q3V1A4
    Related
    ENSMUSP00000144828.2, ENSMUST00000204542.3
    Conserved Domains (1) summary
    pfam00243
    Location:158267
    NGF; Nerve growth factor family
  3. NM_008742.3NP_032768.1  neurotrophin-3 isoform b preproprotein

    See identical proteins and their annotated locations for NP_032768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA198264, AK132586, BC065785, CJ049238
    Consensus CDS
    CCDS20553.1
    UniProtKB/Swiss-Prot
    P20181
    UniProtKB/TrEMBL
    Q3V1A4
    Related
    ENSMUSP00000052302.8, ENSMUST00000050484.9
    Conserved Domains (1) summary
    pfam00243
    Location:145254
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    126078375..126143734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505715.4XP_006505778.1  neurotrophin-3 isoform X1

    Conserved Domains (1) summary
    pfam00243
    Location:165274
    NGF; Nerve growth factor family
  2. XM_006505716.3XP_006505779.1  neurotrophin-3 isoform X2

    See identical proteins and their annotated locations for XP_006505779.1

    UniProtKB/Swiss-Prot
    P20181
    Conserved Domains (1) summary
    pfam00243
    Location:145254
    NGF; Nerve growth factor family
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