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Ntn1 netrin 1 [ Mus musculus (house mouse) ]

Gene ID: 18208, updated on 9-Oct-2021

Summary

Official Symbol
Ntn1provided by MGI
Official Full Name
netrin 1provided by MGI
Primary source
MGI:MGI:105088
See related
Ensembl:ENSMUSG00000020902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Netr; AI561871; BC019633; Netrin-1
Expression
Ubiquitous expression in lung adult (RPKM 25.3), colon adult (RPKM 12.9) and 23 other tissues See more
Orthologs
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Genomic context

See Ntn1 in Genome Data Viewer
Location:
11; 11 B3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68100190..68277652, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68209364..68386826, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68022866..68200328, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 52 Neighboring gene syntaxin 8 Neighboring gene ribosomal protein L31 pseudogene Neighboring gene microRNA 6406 Neighboring gene predicted gene, 31954 Neighboring gene predicted gene, 32046

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within anterior/posterior axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in chemorepulsion of axon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland duct morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nuclear migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse assembly EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substrate-dependent cell migration, cell extension ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008744.2NP_032770.2  netrin-1 precursor

    See identical proteins and their annotated locations for NP_032770.2

    Status: VALIDATED

    Source sequence(s)
    AI840271, AL669842, BE652257, CF537666, CF585515, U65418
    Consensus CDS
    CCDS24864.1
    UniProtKB/Swiss-Prot
    O09118
    Related
    ENSMUSP00000021284.3, ENSMUST00000021284.4
    Conserved Domains (4) summary
    smart00136
    Location:46283
    LamNT; Laminin N-terminal domain (domain VI)
    cd00055
    Location:403451
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:487601
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
    pfam00053
    Location:341394
    Laminin_EGF; Laminin EGF domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68100190..68277652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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