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Ntn3 netrin 3 [ Mus musculus (house mouse) ]

Gene ID: 18209, updated on 5-Mar-2024

Summary

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Official Symbol
Ntn3provided by MGI
Official Full Name
netrin 3provided by MGI
Primary source
MGI:MGI:1341188
See related
Ensembl:ENSMUSG00000117406 AllianceGenome:MGI:1341188
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ntn2l
Summary
Enables signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Predicted to act upstream of or within myoblast fusion and regulation of transcription, DNA-templated. Located in Golgi apparatus and extracellular region. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; nervous system; and tooth. Orthologous to human NTN3 (netrin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 9.9), ovary adult (RPKM 3.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Ntn3 in Genome Data Viewer
Location:
17 A3.3; 17 12.31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24422805..24428361, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24203831..24209387, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42075 Neighboring gene amidohydrolase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-seq mESC enhancer starr_42079 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene tubulin epsilon and delta complex 2 Neighboring gene cyclin F Neighboring gene microRNA 5134

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons. Seaman C, et al. Mech Dev, 2001 Mar. PMID 11231084
  2. Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord. Kennedy TE, et al. J Neurosci, 2006 Aug 23. PMID 16928876, Free PMC Article
  3. Divergent properties of mouse netrins. PuschelPüschel AW. Mech Dev, 1999 May. PMID 10381568
  4. Developmentally regulated expression of Netrin-1 and -3 in the embryonic mouse molar tooth germ. Løes S, et al. Dev Dyn, 2003 Aug. PMID 12889066
  5. Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. Jiang Y, et al. Dev Biol, 2003 Jun 15. PMID 12798294

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory Axons.
    Title: Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory Axons.
  2. netrin-3 and neogenin may promote myogenic differentiation by an autocrine mechanism as components of a higher order complex of several promyogenic cell surface proteins
    Title: Netrins and neogenin promote myotube formation.
  3. Netrin-3 is expressed by the fetal mucosal epithelium and pancreas.
    Title: Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within myoblast fusion ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
netrin-3
Names
netrin-2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010947.3 → NP_035077.1  netrin-3 precursor

    See identical proteins and their annotated locations for NP_035077.1

    Status: PROVISIONAL

    Source sequence(s)
    BC094362
    Consensus CDS
    CCDS28478.1
    UniProtKB/Swiss-Prot
    Q9QY49, Q9R1A3, Q9WVA6
    UniProtKB/TrEMBL
    Q52KG2
    Related
    ENSMUSP00000024931.5, ENSMUST00000024931.6
    Conserved Domains (4) summary
    cd00055
    Location:373 → 422
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:456 → 562
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
    pfam00053
    Location:311 → 362
    Laminin_EGF; Laminin EGF domain
    cl02806
    Location:34 → 253
    Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24422805..24428361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1A3.1 GenPept UniProtKB/Swiss-Prot:Q9R1A3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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