Numbl numb-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Numblprovided by MGI
Official Full Name: numb-likeprovided by MGI
Primary source: MGI:MGI:894702
See related: Ensembl:ENSMUSG00000063160 AllianceGenome:MGI:894702
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: nbl
Summary: Involved in lateral ventricle development; neuroblast division in subventricular zone; and positive regulation of neurogenesis. Acts upstream of or within adherens junction organization and nervous system development. Located in cytoplasm. Is expressed in several structures, including central nervous system; peripheral nervous system ganglion; sensory organ; testis; and thymus. Orthologous to human NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 20.9), limb E14.5 (RPKM 20.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 15.86 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (26957884..26981570)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (27258438..27282150)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Numb and Numblike regulate sarcomere assembly and maintenance.
Title: Numb and Numblike regulate sarcomere assembly and maintenance.
Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis.
Title: Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis.
our data suggest that NUMBL and TAK1 are reciprocally regulated and that NUMBL acts as an endogenous regulator of NF-kappaB signaling and osteoclastogenesis by targeting the TAK1-TRAF6-NEMO axis.
Title: NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis.
investigations revealed that NUMB and NUMBL interacted with small GTPase Rab7 to transition ERBB2 from early to late endosome for degradation.
Title: Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.
These findings highlight the importance of Numb and Numbl in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis
Title: Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis.
findings demonstrate that Nb and Nbl are intrinsic factors crucial for the renewal of CPCs in the PA2 and that the PA2 serves as a microenvironment for their expansion
Title: Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors.
Numb/Numbl control VEGF receptor endocytosis, signaling, and recycling in endothelial cells, which promotes the angiogenic growth of blood vessels.
Title: Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like.
By ablating Numb and Numbl in different cardiac populations followed by lineage tracing, we determined that Numb and Numbl in the second heart field are required for outflow tract (OFT) and atrioventricular septation and OFT alignment.
Title: Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation.
Concomitant but not separate ablation of Numb and Numblike in the developing heart leads to increased Notch2 activity along with hypertrabeculation, reduced compaction, and ventricular septum defects.
Title: Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.
Numbl is a physiologically relevant target of miR-34a in neural progenitor cells, allowing for enhanced Notch signaling and inhibition of neuronal differentiation.
Title: MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129503 (e-PCR)
- UniSTS:212807

G67956 (e-PCR)
- UniSTS:225670

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within adherens junction organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast division in subventricular zone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: numb-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417032.1 → NP_001403961.1 numb-like protein isoform 1

Status: VALIDATED

Source sequence(s)

AC157561
NM_001417033.1 → NP_001403962.1 numb-like protein isoform 3

Status: VALIDATED

Source sequence(s)

AC157561

UniProtKB/TrEMBL

Q3UH86
NM_010950.3 → NP_035080.2 numb-like protein isoform 2

See identical proteins and their annotated locations for NP_035080.2

Status: VALIDATED

Source sequence(s)

AC157561

Consensus CDS

CCDS21016.1

UniProtKB/Swiss-Prot

O08919, Q4QQQ2, Q6NVG8

Related

ENSMUSP00000078245.7, ENSMUST00000079258.7

Conserved Domains (2) summary

cd01268
Location:64 → 198

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:287 → 371

NumbF; NUMB domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

26957884..26981570

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250452.2 → XP_011248754.1 numb-like protein isoform X1

Conserved Domains (3) summary

PHA03247
Location:259 → 498

PHA03247; large tegument protein UL36; Provisional

cd01268
Location:64 → 198

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:289 → 371

NumbF; NUMB domain
XM_030242207.2 → XP_030098067.1 numb-like protein isoform X3

UniProtKB/TrEMBL

Q3UH86

Conserved Domains (3) summary

PHA03247
Location:218 → 549

PHA03247; large tegument protein UL36; Provisional

cd01268
Location:23 → 157

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:248 → 330

NumbF; NUMB domain
XM_006539615.3 → XP_006539678.1 numb-like protein isoform X2

See identical proteins and their annotated locations for XP_006539678.1

Conserved Domains (3) summary

PHA03247
Location:263 → 594

PHA03247; large tegument protein UL36; Provisional

cd01268
Location:68 → 202

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:293 → 375

NumbF; NUMB domain